Results 91 to 100 of about 9,117,557 (397)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The real-time infection hospitalisation and fatality risk across the COVID-19 pandemic in England

Nature Communications
The COVID-19 pandemic led to 231,841 deaths and 940,243 hospitalisations in England, by the end of March 2023. This paper calculates the real-time infection hospitalisation risk (IHR) and infection fatality risk (IFR) using the Office for National ...
Thomas Ward, Martyn Fyles, Alex Glaser, Robert S. Paton, William Ferguson, Christopher E. Overton   +5 more
doaj   +1 more source

‘Next-Generation’ surveillance: an epidemiologists’ perspective on the use of molecular information in food safety and animal health decision-making [PDF]

, 2015
Advances in the availability and affordability of molecular and genomic data are transforming human health care. Surveillance aimed at supporting and improving food safety and animal health is likely to undergo a similar transformation.
Dufour, S., Muellner, P., Stärk, K.D.C., Zadoks, R.N.   +3 more
core   +1 more source

Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases

Frontiers in Public Health, 2019
Infections caused by pathogens commonly acquired from consumption of food are not always transmitted by that route. They may also be transmitted through contact to animals, other humans or the environment. Additionally, many outbreaks are associated with
P. Gerner-Smidt, J. Besser, Jeniffer Concepción-Acevedo, J. Folster, J. Huffman, L. Joseph, Z. Kučerová, M. Nichols, Colin A. Schwensohn, B. Tolar   +9 more
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Whole-genome sequencing for national surveillance of Shiga toxin–producing Escherichia coli O157 [PDF]

, 2015
Background. National surveillance of gastrointestinal pathogens, such as Shiga toxin–producing Escherichia coli O157 (STEC O157), is key to rapidly identifying linked cases in the distributed food network to facilitate public health interventions.
Adak, Goutam, Ashton, Philip M., Byrne, Lisa, Cowley, Lauren A, Dallman, Timothy J, Ellis, Richard J, Elson, Richard, Grant, Kathie, Green, Jonathan, Hanage, William P, Jenkins, Claire, Perry, Neil T, Petrovska, Liljana, Underwood, Anthony, Wain, John   +14 more
core   +1 more source

Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation.

Annual Review of Public Health, 2017
Surveillance is critical for improving population health. Public health surveillance systems generate information that drives action, and the data must be of sufficient quality and with a resolution and timeliness that matches objectives.
S. Groseclose, D. Buckeridge
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Primary leptomeningeal histiocytic lymphoproliferative disorder associated with SARS-CoV-2 brain infection in k18-hACE2 mouse: a case report

Laboratory Animal Research
Background Histiocytic proliferative disorders in the central nervous system are rare, and their potential association with viral infections remains largely unexplored.
Néstor Porras, Lidia Sánchez-Morales, Marta Pérez-Sancho, Lucas Domínguez, Antonio Rodríguez-Bertos   +4 more
doaj   +1 more source