Results 71 to 80 of about 9,860,066 (398)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Ontological representation of CDC Active Bacterial Core Surveillance Case Reports [PDF]

, 2014
The Center for Disease Control and Prevention’s Active Bacterial Core Surveillance (CDC ABCs) Program is a collaborative effort betweeen the CDC, state health departments, laboratories, and universities to track invasive bacterial pathogens of particular
Cowell, Lindsay G., Goldfain, Albert, Smith, Barry   +2 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rotavirus antigenemia as a common event among children hospitalised for severe, acute gastroenteritis in Belém, northern Brazil

BMC Pediatrics, 2019
Background Rotavirus antigenemia and RNAemia (the presence of rotavirus RNA in serum) have been commonly identified among paediatric patients with acute gastroenteritis. In this study we examined the association between rotavirus antigenemia and clinical
Maria Cleonice A. Justino, Erika A. Campos, Joana D’arc P. Mascarenhas, Luana S. Soares, Sylvia de Fátima S. Guerra, Ismari P. Furlaneto, Manoel Jaime C. Pavão Jr, Tassio S. Maciel, Fredison P. Farias, Orvácio M. Bezerra, Caio Breno G. Vinente, Rodrigo José S. Barros, Alexandre C. Linhares   +12 more
doaj   +1 more source

COVID-19 epidemic monitoring after non-pharmaceutical interventions: The use of time-varying reproduction number in a country with a large migrant population

International Journal of Infectious Diseases, 2020
Background: COVID-19’s emergence carries with it many uncertainties and challenges, including strategies to manage the epidemic. Oman has implemented non-pharmaceutical interventions (NPIs) to mitigate the impact of COVID-19.
Adil Al Wahaibi, Abdullah Al Manji, Amal Al Maani, Bader Al Rawahi, Khalid Al Harthy, Fatma Alyaquobi, Amina Al-Jardani, Eskild Petersen, Seif Al Abri   +8 more
doaj   +1 more source

Malaria vaccine coverage estimation using age-eligible populations and service user denominators in Kenya

Malaria Journal, 2023
Background The World Health Organization approved the RTS,S/AS01 malaria vaccine for wider rollout, and Kenya participated in a phased pilot implementation from 2019 to understand its impact under routine conditions.
Angela K. Moturi, Rose Jalang’o, Anitah Cherono, Samuel K. Muchiri, Robert W. Snow, Emelda A. Okiro   +5 more
doaj   +1 more source

Syndromic surveillance to assess the potential public health impact of the Icelandic volcanic ash plume across the United Kingdom, April 2010 [PDF]

, 2010
The Eyjafjallajökull volcano in Iceland erupted on 14 April 2010 emitting a volcanic ash plume that spread across the United Kingdom and mainland Europe.
Catchpole, M., Elliott, A.J., Harcourt, S., Ibbotson, S., Kavanagh, K., Kibble, A., Loveridge, P., McCloskey, B., McMenamin, J., Murray, V., Pnaiser, R., Ramsay, C.N., Robertson, C., Singh, N., Smith, G.E., Smith, S.   +15 more
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Genomic epidemiology of Mycobacterium tuberculosis in Wales

Scientific Reports
Identification of factors contributing to tuberculosis (TB) transmission can guide targeted measures to reduce morbidity. Varying findings for factors associated with TB genomic clustering exist.
Nicole Pacchiarini, Felicity Simkin, Mark Postans, George Ahern, Jiao Song, Clare Brown, Josie Smith, Catie Williams, Matthijs Backx, Daniel Thomas, Thomas R. Connor, Christopher Williams   +11 more
doaj   +1 more source

An Outbreak of Aeromonas salmonicida in Juvenile Siberian Sturgeons (Acipenser baerii)

Animals, 2023
Aeromonas salmonicida is one of the major threats to world aquaculture, causing fish furunculosis and high mortality rates in cultured fish, particularly salmonids. Although Aeromonas spp.
Esther Vázquez-Fernández, Blanca Chinchilla, Agustín Rebollada-Merino, Lucas Domínguez, Antonio Rodríguez-Bertos   +4 more
doaj   +1 more source