Results 141 to 150 of about 849,913 (310)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
National Center for Health Statistics; programs and activities-- monitoring the nation's health
The National Center for Health Statistics (NCHS) is a unique public resource for health information. As the Nation\u2019s principal health statistics agency, NCHS provides statistical information to guide actions and policies to improve the health of the
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
National Health and Nutrition Examination Survey : 2022 interviewer procedures manual
This chapter introduces you to the National Health and Nutrition Examination Survey (NHANES).This chapter provides:\u2022 A brief history of the initial health examination surveys conducted by the National Center for Health Statistics (NCHS) and the ...
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The Data for Health initiative is a partnership between the Centers for Disease Control and Prevention (CDC), the CDC Foundation, Bloomberg Philanthropies and other organizations to assist 20 low- and middle-income countries across Latin America, Asia ...
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The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Linkage of NCHS population health surveys to administrative records from Social Security Administration and Centers for Medicare & Medicaid Services [PDF]
Background: As the nation\u2019s principal health statistics agency, the National Center for Health Statistics (NCHS) provides statistical information that can be used to guide actions and policy to improve the health of the American people.
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