Self-reported sexually transmitted infections among adolescents and adults in Zambia and Zimbabwe: evidence from Demographic and Health Surveys, 2005-2018. [PDF]
BMJ OpenRotsaert A +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
No easy answer for how to tackle Mexico's health challenges
The Lancet Global Health, 2016 Juan Pablo Gutiérrez +1 more
doaj +1 more source
Obstetric fistula awareness in The Gambia, Côte d'Ivoire, Madagascar and Sierra Leone: A cross-sectional analysis of Demographic and Health Surveys data. [PDF]
J Public Health AfrPierce H, Leclerc E, Peterson N.
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Financial barriers and inequalities in healthcare access across East Africa: evidence from demographic and health surveys. [PDF]
Front Reprod HealthFarih OA +6 more
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Assessing the efficiency of HIV prevention interventions in Kenya – the ORPHEA Project
Annals of Global Health, 2015 R. Wamai +12 more
doaj +1 more source
Tendência secular da anemia na infância na cidade de São Paulo (1984-1996)
Revista de Saúde PúblicaOBJETIVO: Estimar a prevalência e a distribuição social da anemia na infância, estabelecer a tendência secular dessa enfermidade e analisar sua determinação, com base em dados coletados por dois inquéritos domiciliares realizados na cidade de São Paulo ...
Carlos Augusto Monteiro +2 more
doaj