Results 141 to 150 of about 6,736,762 (309)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Reformas de los sistemas de salud en Sudamérica: una oportunidad para UNASUR
Revista Peruana de Medicina Experimental y Salud PúblicaLos sistemas de salud de América del Sur siguen soportando la segmentación, la privatización y la fragmentación. Las reformas del sector salud de los programas de ajuste estructural de los años 1980 y 1990 en Sudamérica siguieron diferentes propósitos y ...
José Gomes-Temporão, Mariana Faria
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
How to improve public health systems : lessons from Tamil Nadu [PDF]
Public health systems in India have weakened since the 1950s, after central decisions to amalgamate the medical and public health services, and to focus public health work largely on single-issue programs - instead of on strengthening public health ...
Das Gupta, Monica +3 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
EIRP Proceedings, 2008 One of the main objectives of the Programme of Community Action în the Field of PublicHealth (2003-2008) is to improve the analysis and knowledge of the impact of health policy developments and ofother Community policies and activities.
Costinela Georgescu, Gabriela Dragomir
doaj
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Social Medicine, 2014 Objectives: In order to improve the care provided at a rural consultorio, we obtained patients’ perspectives on the successes and failures of the Chilean healthcare system under the AUGE (Acceso Universal de Garantías Explícitas, Universal Access with ...
Caitlin Schrepel +3 more
doaj