Results 61 to 70 of about 205,504 (307)

Improving the use of health data for health system strengthening

Global Health Action, 2013
BackgroundGood quality and timely data from health information systems are the foundation of all health systems. However, too often data sit in reports, on shelves or in databases and are not sufficiently utilised in policy and program development, improvement, strategic planning and advocacy.
Tara Nutley, Heidi W. Reynolds
openaire   +3 more sources

Strengthening the Oral Health System in Nigeria

Nigerian Postgraduate Medical Journal, 2022
Aim: The present study aimed to describe the building blocks of the oral health system, including the role that the community plays in strengthening the oral health system in Nigeria. Methodology: This research was a scoping review of the existing literature retrieved from search ...
Mcking Izeiza Amedari, Eyitope O Ogunbodede, Omolara G Uti, Adetayo O Aborisade, Ifeoma Katerine Amedari   +4 more
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Application of ICT in Strengthening Health Information Systems in Developing Countries in the Wake of Globalisation. [PDF]

, 2004
Information Communication Technology (ICT) revolution brought opportunities and challenges to developing countries in their efforts to strengthen the Health Management Information Systems (HMIS). In the wake of globalisation, developing countries have no
Simba, Daudi O, Mwangu, Mughwira
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Strengthening capacity to apply health research evidence in policy making: experience from four countries [PDF]

, 2016
Increasing the use of evidence in policy making means strengthening capacity on both the supply and demand sides of evidence production. However, little experience of strengthening the capacity of policy makers in low- and middle- income countries has ...
K Aulakh, B, Whitworth, J, Jadeja, Nidhee, Barge, S, Hawkes, Sarah, Ghaffar, Abdul, Anwar, Iqbal, Jimenez, Michelle, Odubanjo, M Oladoyin, Jadeja, N, Ghaffar, A, Anwar, I, Jimenez, M, Hawkes, S, Shukla, A, Shukla, Abhay, Odubanjo, MO, K Aulakh, Bhupinder, Buse, K, Buse, Kent, Barge, Sandhya, Whitworth, Jimmy   +21 more
core   +1 more source

Challenges of using e-health technologies to support clinical care in rural Africa: a longitudinal mixed methods study exploring primary health care nurses’ experiences of using an electronic clinical decision support system (CDSS) in South Africa

BMC Health Services Research, 2023
Background Electronic decision-making support systems (CDSSs) can support clinicians to make evidence-based, rational clinical decisions about patient management and have been effectively implemented in high-income settings.
Christiane Horwood, Silondile Luthuli, Sphindile Mapumulo, Lyn Haskins, Cecilie Jensen, Deidre Pansegrouw, Neil McKerrow   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Measuring health system strengthening: application of the balanced scorecard approach to rank the baseline performance of three rural districts in Zambia. [PDF]

, 2013
INTRODUCTION: There is growing interest in health system performance and recently WHO launched a report on health systems strengthening emphasising the need for close monitoring using system-wide approaches.
Peter Godfrey-Fausset, Mwanamwenge Margaret Tembo, Godfrey-Fausset, Peter, Spicer, Neil, Spicer Neil, Chintu, Namwinga, Mutale, Wilbroad, Ayles, Helen, Helen Ayles, Kasese, Nkatya, Godfrey-Fausset Peter, Kasese Nkatya, Namwinga Chintu, Wilbroad Mutale, Ayles Helen, Mutale Wilbroad, Balabanova, Dina, Mwanamwenge, Margaret Tembo, Margaret Tembo Mwanamwenge, Nkatya Kasese, Dina Balabanova, Neil Spicer, Balabanova Dina, Chintu Namwinga   +23 more
core   +1 more source