Results 81 to 90 of about 205,504 (307)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The impact of governance in primary health care delivery: a systems thinking approach with a European panel [PDF]

, 2019
Enhancing primary health care (PHC) is considered a policy priority for health systems strengthening due to PHC’s ability to provide accessible and continuous care and manage multimorbidity.
Marti, Joachim, Darzi, A., Espinosa-González, A.B., Marti, J., Espinosa-González, Ana Belén, Delaney, Brendan C, Delaney, B.C., Darzi, Ara   +7 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

DRAFT Report:Community Systems Strengthening Toward a Research Agenda

, 2014
Communities have a long history of acting to preserve and promote the health of their members. Public health researchers, programmers, and funders are increasingly recognizing that community involvement is essential to improving health, especially among ...
Ayala, George, Chong, Susan, Greenall, Matthew, Arreola, Sonya, Mallouris, Christoforos   +4 more
core  

Guidance for evidence-informed policies about health systems: linking guidance development to policy development. [PDF]

, 2012
In the second paper in a three-part series on health systems guidance, John Lavis and colleagues explore the challenge of linking guidance development and policy development at global and national ...
Atun, Rifat, Lewin, Simon, Lavis John N., Haines, A., Sandy Oliver (176682), Rottingen, John-Arne, Lavis, J. N., John-Arne Røttingen, Gilson, L., Andy Haines, John N Lavis, Bosch-Capblanch Xavier, Atun Rifat, Haines, Andy, Gilson, Lucy, Oliver Sandy, Røttingen, John-Arne, Fadi El-Jardali (176708), Simon Lewin, Rifat Atun (109572), Lewin, S., Andy Haines (102671), Pierre Ongolo-Zogo, Rottingen, J. A., El-Jardali, F., El-Jardali Fadi, Ongolo-Zogo Pierre, Ongolo-Zogo, Pierre, John-Arne Røttingen (135631), Rifat Atun, Simon Lewin (176675), Lewin Simon, Lavis, John, Lucy Gilson, Oliver, Sandy, Lucy Gilson (177765), Gilson Lucy, Xavier Bosch-Capblanch, Fadi El-Jardali, Pierre Ongolo-Zogo (117468), Ongolo-Zogo, P., El-Jardali, Fadi, Røttingen John-Arne, Xavier Bosch-Capblanch (176679), Sandy Oliver, Bosch-Capblanch, X., Oliver, S., Lavis, John N, Atun, R., John N. Lavis (176694), Bosch-Capblanch, Xavier, Haines Andy   +51 more
core   +1 more source

The year 2020, a milestone in breaking the vicious cycle of poverty and illness in China

Infectious Diseases of Poverty, 2020
Marking the end of the five-year programme initiated by the Chinese Government to lift more than 70 million people out of poverty, the year 2020 is a milestone.
Yun-Ping Wang, Xiao-Nong Zhou
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Strengthening public health in South Africa: building a stronger evidence base for improving the health of the nation. [PDF]

, 2007
No Abstract. South African Medical Journal Vol. 97 (8) Part 2 2007: pp.
Lewin, Simon, Schneider, Michelle, Laubscher, R, Joubert, J, Groenewald, Pam, Nojilana, Beatrice, Pieterse, Desiréé, Nannan, N, Norman, Rosana, Steyn, K, Matzopoulos, R, South African Comparitive Risk Assessment Collaboration Grou,, Nojilana, B, Vos, Theo, Lewin, S, Joubert, Jané, Pieterse, D, Nannan, Nadine, Bradshaw, Debbie, Laubscher, Ria, Matzopoulos, Richard, Bradshaw, D, Schneider, M, Vos, T, Norman, R, Steyn, Krisela, South African Comparative Risk Assessment Collaborating Group, Groenewald, P   +27 more
core