Results 61 to 70 of about 5,541,202 (305)

Redefining Rare Disease Care in the Digital Age: Insights and Key Takeaways from a Digital Health Symposium Focused on Empowering Rare Disease Communities

open access: yesBiomedicine Hub
At the Stanford-UCB Rare Disease Digital Health Symposium held in Stanford, California, on September 8, 2023, researchers, clinicians, payers, thought leaders, and rare disease caregivers and advocates discussed the current state of care delivery and ...
Emily Lewis, Anuradha Dayal, Ron Li
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Towards a Unified European View of Clinical Evidence: What ‘Health Technology Assessment Organizations’ Can Learn from Regulatory Experience

open access: yesJournal of Market Access & Health Policy
The harmonization of pharmaceutical regulations within the European Union has been a crucial step towards ensuring high safety standards and efficient access to innovative medicines.
Karl Broich, Wiebke Löbker
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Enhancing the Capacity of Community Health Centers to Achieve High Performance [PDF]

open access: yes, 2010
Based on a survey of community health centers, assesses access to care, care coordination, quality improvement efforts, health information technology adoption, and ability to serve as patient-centered medical homes.
Anne C. Beal   +4 more
core  

Economic evaluation of laparoscopic surgery for colorectal cancer [PDF]

open access: yes, 2007
Objectives: To assess the cost-effectiveness of laparoscopic surgery compared with open surgery for the treatment of colorectal cancer. Methods: A Markov model was developed to model cost-effectiveness over 25 years.
Aberdeen Health Technology Assessment Group   +3 more
core   +1 more source

Prioritizing health system and disease burden factors: an evaluation of the net benefit of transferring health technology interventions to different districts in Zimbabwe

open access: yesClinicoEconomics and Outcomes Research, 2016
Shepherd Shamu,1 Simbarashe Rusakaniko,1 Charles Hongoro,2 1Department of Community Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe; 2Human Sciences Research Council of South Africa Introduction: Health-care technologies ...
Shamu S, Rusakaniko S, Hongoro C
doaj  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Rising health spending, new medical technology and the Baumol effect [PDF]

open access: yes
This paper estimates the Baumol effect in health spending, using a panel data set of OECD countries. Health expenditure as a share of GDP rises in most OECD countries.
Marc Pomp, Suncica Vujic
core  

mHealth in China and the United States: How Mobile Technology is Transforming Healthcare in the World's Two Largest Economies [PDF]

open access: yes, 2014
In this paper, we explore ways mobile technology can help with these difficulties. Specifically, we look at avenues through which mobile devices boost productivity, aid communications, and help providers improve affordability, access, and treatment ...
Darrell West   +11 more
core  

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