Results 51 to 60 of about 22,551,970 (267)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Quantifying Induced Nystagmus Using a Smartphone Eye Tracking Application (EyePhone)

open access: yesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background There are ≈5 million annual dizziness visits to US emergency departments, of which vestibular strokes account for over 250 000. The head impulse, nystagmus, and test of skew eye examination can accurately distinguish vestibular strokes from ...
Pouya B. Bastani   +8 more
doaj   +1 more source

Pedagogy as Possibility: Health Interventions as Digital Openness

open access: yesSocial Sciences, 2017
In this article we propose an approach to digital health tracking technologies that draws on design anthropology. This entails re-thinking the pedagogical importance of personal data as lying in how they participate in the constitution of new ...
Vaike Fors, Sarah Pink
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Comparison of Nurses’ Digital Literacy Levels: A Study in Digital and Non-Digital Hospitals

open access: yesForbes Tıp Dergisi
Objective: The aim of this study is to compare the digital literacy levels of nurses working in digital and non-digital hospitals and to examine the effect of demographic and professional variables on their digital competence.
Mustafa ORHAN, Süleyman MERTOĞLU
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

In vivo physiology of gap junctions between supporting cells in the organ of Corti [PDF]

open access: yes, 1999
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, February 1999.Includes bibliographical references (p.
Oberoi, Pankaj
core  

Rethinking the digital divide in health: a critical interpretive synthesis of research literature

open access: yesFrontiers in Digital Health
BackgroundThe digital divide in health has rapidly expanded during and after the COVID-19 pandemic, with fragmented understanding and an unclear implementation process, for the formal integration of digital health into the healthcare system, which ...
Meghan Bradway   +9 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Integrating thermal liquid biopsy, clinical data, and mass spectrometry for early diagnosis and biomarker discovery in colorectal cancer

open access: yesiScience
Summary: Early detection of colorectal cancer is essential to improving survival, where yet current diagnostic tools show limited performance. This study aimed to enhance diagnostic accuracy by integrating clinical variables with thermogram profiles ...
Sonia Hermoso-Durán   +15 more
doaj   +1 more source

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