Results 51 to 60 of about 5,578,781 (262)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Towards a Unified European View of Clinical Evidence: What ‘Health Technology Assessment Organizations’ Can Learn from Regulatory Experience

open access: yesJournal of Market Access & Health Policy
The harmonization of pharmaceutical regulations within the European Union has been a crucial step towards ensuring high safety standards and efficient access to innovative medicines.
Karl Broich, Wiebke Löbker
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Prioritizing health system and disease burden factors: an evaluation of the net benefit of transferring health technology interventions to different districts in Zimbabwe

open access: yesClinicoEconomics and Outcomes Research, 2016
Shepherd Shamu,1 Simbarashe Rusakaniko,1 Charles Hongoro,2 1Department of Community Medicine, College of Health Sciences, University of Zimbabwe, Harare, Zimbabwe; 2Human Sciences Research Council of South Africa Introduction: Health-care technologies ...
Shamu S, Rusakaniko S, Hongoro C
doaj  

The Federal Role in Promoting Health Information Technology [PDF]

open access: yes, 2009
Outlines the need to expand adoption of health information technology to improve healthcare quality and efficiency; the financial, technical, and logistical challenges; and providers' concerns.
David Blumenthal
core  

The role of technology in music listening for health and wellbeing [PDF]

open access: yes, 2015
There is growing evidence that listening to music can have significant effects upon health and wellbeing. This article briefly summarises research examining the effects of music listening on a variety of health parameters, and explores the potential role
Knox, Don, MacDonald, Raymond
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

In-community vision testing device development using a Kaupapa Māori framework

open access: yesKōtuitui
We report on a 2019 project in which we ran in-community testing of a novel device for measuring visual acuity (the measure of performance obtained by an eye chart).
Jason Turuwhenua   +2 more
doaj   +1 more source

Health Informatics, Sustainable Health Care Development and Malnutrition in India [PDF]

open access: yes, 2011
Health informatics aims at studying the principal computer applications related to technology in developing human health care and solving the existing problems to facilitate efficient management.
Balgir, RS
core  

We are bitter, but we are better off: Case study of the implementation of an electronic health record system into a mental health hospital in England [PDF]

open access: yes, 2012
In contrast to the acute hospital sector, there have been relatively few implementations of integrated electronic health record (EHR) systems into specialist mental health settings. The National Programme for Information Technology (NPfIT) in England was
Barber, N, Sheikh, A, Takian, A
core   +5 more sources

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