Results 151 to 160 of about 979,842 (317)

Health Technology Case Study 26: Assistive Devices for Severe Speech Impairments [PDF]

, 1983
A case study by the Office of Technology Assessment (OTA) that is "about the revolution in communication aids that has since changed the outlook for this population [nonspeaking population], its accomplishments to date, its promise for the future, and ...
United States. Congress. Office of Technology Assessment.
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Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Strategic plan 1994

, 2014
In this plan the Mission and Objectives of BCOHTA are reviewed together with an assessment of the internal and external environments and an evaluation of the results to date.
British Columbia Office of Health Technology Assessment
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Health Care Technology Case Study 28: Intensive Care Units (ICUs): Clinical Outcomes, Costs, and Decisionmaking [PDF]

, 1984
A case study by the Office of Technology Assessment (OTA) that presents "what is currently known about ICUs in terms of the distribution of ICU beds, the costs of maintaining ICUs, the characteristics of ICU patients and the outcome of ICU care" (p. 3)
United States. Congress. Office of Technology Assessment.
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Correction: A systematic literature review of economic evaluation studies of interventions impacting antimicrobial resistance

Antimicrobial Resistance and Infection Control, 2023
Chris Painter, Dian Faradiba, Kinanti Khansa Chavarina, Ella Nanda Sari, Yot Teerawattananon, Kristina Aluzaite, Aparna Ananthakrishnan   +6 more
doaj   +1 more source

Effectiveness and safety of biological and target synthetic drugs treatment for psoriatic arthritis: a systematic review with network meta-analysis

Advances in Rheumatology
Background Psoriatic arthritis (PA) is a chronic inflammatory systemic arthritis that can result in loss of functional capacity and joint deformation. This systematic review assessed the effectiveness and safety of biological and target synthetic drugs ...
Thais Montezuma, Livia Fernandes Probst, Matheus Oliveira Almeida   +2 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Surgeon's views of health technology assessment in Australia: Online pilot survey

, 2013
Introduction: Many governments have introduced health technology assessment (HTA) as an important tool to manage the uptake and use of health-related technologies efficiently.
Van Gool, K, van Gool, K., Gallego, G, Casey, Robert, Maddern, Guy, Gallego, G., Maddern, G., Casey, R., Gallego, Gisselle (R16900), Casey, R, Maddern, G, Gool, Kees van   +11 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Health insurance : the Hawaii experience / [PDF]

, 1993
"BP-H-108"--P. [4] of cover."Prepared as background for OTA's Assessment Technology, Insureance, and the Health Care system"--Foreword.Mode of access ...
Lawrence H. Miike, United States. Congress. Office of Technology Assessment., Miike, Lawrence H., United States. Congress. Office of Technology Assessment.   +3 more
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