Results 141 to 150 of about 934,440 (269)

Ethical Considerations in Health Technology Assessment for Precision Medicine: A Delphi Study in a Greek Setting. [PDF]

J Pers Med
Veskoukis N, Stefanopoulos N, Naoum P, Athanasakis K.   +3 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Patient involvement in health technology assessment: a new process in Singapore. [PDF]

Int J Technol Assess Health Care
Tan PT, Pearce F, Quek KS, Teo SH, Koh JH.   +4 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Methodological guidelines for Health Technology Assessment in Oman. [PDF]

J Pharm Policy Pract
Wani S, Alsabti H, Allamki S, Almandhari A, Alhajji S, Alrashdi I, Al Sabri R, Alqassabi A, Alzaabi A, Almaashani A, Ashuaili A, Rasool A, Alkindi A, Salman B, Alzadjali F, Al Rahbi K, Almutawa K, Alansari M, AlKharusi M, AlBulushi N, Alghadani R, Aljaber R, Almuaini S, Alkindi S, Alzawamri S, Albalushi S, Al Lawati S, Alsalti Z, AlBalushi H, Fasseeh AN, Kaló Z.   +30 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Early health technology assessment: current and future perspectives from a health technology assessment agency. [PDF]

Int J Technol Assess Health Care
Jarrom D.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Technology Assessment and Public Health [PDF]

Annual Review of Public Health, 1994
E J, Power, S R, Tunis, J L, Wagner
openaire   +2 more sources

The evolution of cancer therapies and their Implications for health technology assessment in Australia. [PDF]

Cost Eff Resour Alloc
Jones AM, Goodall S, Liew D, Kim H.
europepmc   +1 more source