Results 131 to 140 of about 979,842 (317)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A special report of OTA's assessment on maintaining the defense technology base

, 1988
This special report is the first product of that assessment. It provides an overview of the subject, including specific concerns about the health of the defense technology base and the related issues before Congress. Subsequent reports will probe aspects
United States. Congress. Office of Technology Assessment.
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Health Technology Case Study 35: The Effectiveness and Costs of Continuous Ambulatory Peritoneal Dialysis (CAPD) [PDF]

, 1985
A case study by the Office of Technology Assessment (OTA) over continuous ambulatory peritoneal dialysis (CAPD) as a treatment for end-stage renal disease (p. 3)
United States. Congress. Office of Technology Assessment.
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Health Technology Case Study Twenty-seven: Nuclear Magnetic Resonance Imaging Technology

, 1984
A case study by the Office of Technology Assessment (OTA) that provides "a vehicle for gaining insight into the impact that Federal policies have had on the development of NMR (nuclear magnetic resonance) imaging as a modality, on the industry that ...
United States. Congress. Office of Technology Assessment.
core  

Health Technology Case Study 32: The Hemodialysis Equipment and Disposables Industry [PDF]

, 1984
A case study by the Office of Technology Assessment (OTA) that analyzes the hemodialysis equipment and supplies industry and how it has been shaped by Federal ...
United States. Congress. Office of Technology Assessment.
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Systematic literature review of economic studies on nature-based social prescribing for health improvement

BMC Primary Care
Background Nature-based social prescribing (NBSP) is a form of social prescribing that can enhance mental and/or physical health by connecting participants with nature through non-medical community referrals. While evidence suggests potential benefits of
Sibylle Puntscher, Igor Stojkov, Marjan Arvandi, Felicitas Kühne, Annette Conrads-Frank, Veronika Papon, Daniela Schmid, Beate Jahn, Erica A. Suzumura, Richard Kimberlee, Matthew Jones, Kaisu H. Pitkälä, Anu H. Jansson, Jill S. Litt, Uwe Siebert, Ursula Rochau   +15 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Core competencies for ethics experts in health technology assessment

, 2020
Objectives. There is no consensus on who might be qualified to conduct ethical analysis in the field of health technology assessment (HTA). Is there a specific expertise or skill set for doing this work?
Stanak, Michal,, Sacchini, Dario,, Hofmann, Bjorn,, Autti-Ramo, Ilona,, Mischke, Claudia,, van der Wilt, Gert Jan,, Refolo, Pietro,, Oortwijn, Wija,, Bond, Kenneth,, Bloemen, Bart,, Steele, Duncan,, Sandman, Lars,, Nabukenya, Sylvia,, Mueller, Debjani,   +13 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source