Results 111 to 120 of about 2,804,815 (317)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Cost-effectiveness of HBV and HCV screening strategies:a systematic review of existing modelling techniques [PDF]

, 2015
Introduction: Studies evaluating the cost-effectiveness of screening for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) are generally heterogeneous in terms of risk groups, settings, screening intervention, outcomes and the economic modelling ...
A Tramarin, AA Honeycutt, AG Mulley, AH Miners, AJ Sutton, AJ Sutton, AT Urbanus, BA Plunkett, BP Linas, BR Schackman, BS Bloom, C Rossi, Claudia Geue, Coon J Thompson, David Goldberg, DB Rein, DB Rein, DW Hutton, E Castelnuovo, Elisabeth Fenwick, F Antonanzas, G Sroczynski, G Tormans, IK Veldhuijzen, IL Thomas, J Glanville, J Nakamura, JA Arevalo, JF Jusot, K Stein, K Stein, KL Lapane, LE Cipriano, LJ McGarry, M Ruggeri, M Ruggeri, ME Singer, MF Drummond, MH Eckman, MH Eckman, Natasha K. Martin, Olivia Wu, P Leal, P Zurn, PO Coffin, Robert Heggie, RP Walensky, S Deuffic-Burban, S Liu, S Loubiere, S Loubiere, S-Y Kim, Sharon Hutchinson, SJ Hahne, TS Kwan-Gett, V Josset, Vincent Wong, WW Wong, WWL Wong, Yiqiao Xin, Z Philips   +60 more
core   +5 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The Electronic Health Record Scorecard: A Measure of Utilization and Communication Skills [PDF]

, 2016
As the adoption rate of electronic health records (EHRs) in the United States continues to grow, both providers and patients will need to adapt to the reality of a third actor being present during the visit encounter.
Leamon, Ashley E.
core   +1 more source

Challenges in evaluating surgical innovation [PDF]

, 2009
Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Blazeby, Jane M, Boutron, Isabelle, Clavein, Pierre-Alain, Cook, Jonathan Alistair, Ergina, Patrick L, Reeves, Barnaby C, Seiler, Christoph M   +6 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Breast cancer stage and molecular subtype distribution: real-world insights from a regional oncological center in Hungary

Discover Oncology
Objective Examining the distribution of breast cancer (BC) stage and molecular subtype among women aged below ( 65 years) the recommended screening age range helps to understand the screening program's characteristics and contributes to enhancing the ...
Judit Tittmann, Tamás Ágh, Dalma Erdősi, Bettina Csanády, Erika Kövér, Antal Zemplényi, Sándor Kovács, Zoltán Vokó   +7 more
doaj   +1 more source

Personalized treatment of women with early breast cancer: a risk-group specific cost-effectiveness analysis of adjuvant chemotherapy accounting for companion prognostic tests OncotypeDX and Adjuvant!Online

BMC Cancer, 2017
Background Due to high survival rates and the relatively small benefit of adjuvant therapy, the application of personalized medicine (PM) through risk stratification is particularly beneficial in early breast cancer (BC) to avoid unnecessary harms from ...
Beate Jahn, Ursula Rochau, Christina Kurzthaler, Michael Hubalek, Rebecca Miksad, Gaby Sroczynski, Mike Paulden, Marvin Bundo, David Stenehjem, Diana Brixner, Murray Krahn, Uwe Siebert   +11 more
doaj   +1 more source

Some ethical and legal considerations in the use of Web 2.0 [PDF]

, 2011
This chapter explores ethical and legal issues that need to be considered by health information professionals when using Web 2.0 technologies. It reviews how the Internet and the Web have affected standards of professional behaviour, and highlights the ...
Morgan, Peter
core   +1 more source