Results 101 to 110 of about 2,804,815 (317)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Telemedicine Utilization in Tertiary, Specialized, and Secondary Hospitals in Thailand

Telemedicine Reports
Introduction: COVID-19 has accelerated the adoption of telemedicine for counseling, follow-up examination, and treatment purposes. The official guidelines in Thailand were launched to regulate or frame the protocols for health care professions and teams ...
Piyada Gaewkhiew, Nitichen; Kittiratchakool, Chotika Suwanpanich, Thanayut Saeraneesopon, Thanakit Athibodee, Suthasinee Kumluang, Tanainan Chuanchaiyakul, Sichen Liu, Saranya Chanpanitkitchot, Arthit Laosuangkul, Wanrudee Isaranuwatchai   +10 more
doaj   +1 more source

Transparency in health technology assessments [PDF]

BMJ, 2007
The running battle over which National Health Service patients with dementia should have access to the dementia drug donepezil (Aricept) is to progress to the courts. Last year, guidance from the National Institute for Health and Clinical Excellence (NICE) restricted use of the drug to patients with moderate and severe Alzheimer's disease, thereby ...
openaire   +2 more sources

Health Technology Assessment and Biomedical Engineering : global trends, gaps and opportunities [PDF]

, 2019
The diffusion of medical devices is expanding at an astonishing rate. The increasing number of novel patents per year suggests this growth will continue.
Iadanza, E., Magjarevic, R., Pallikarakis, N., Pecchia, Leandro   +3 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Using XML and XSLT for flexible elicitation of mental-health risk knowledge [PDF]

, 2007
Current tools for assessing risks associated with mental-health problems require assessors to make high-level judgements based on clinical experience. This paper describes how new technologies can enhance qualitative research methods to identify lower ...
A. Ahmed, A. E. Adams, Abernethy M A, Ayyub B M, Boegl K, Bouch J, Buckingham C D, Buckingham C D, Buzan T, C. D. Buckingham, Date C J, Del Fiol G, Dong J, Dotsika F, Harold R E, Higgins N, Holdsworth N, Jacobson D, Jovanović J, Kay M, Kouri P, Maden A, Maruish M E, Mays N, Meyer M A, Monahan J, Neuendorf K A, Novak J D, Siau K, Silverman D, Taminé O, Tomić B, Waterman D A, Watts D   +33 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Health technology assessment in Singapore [PDF]

International Journal of Technology Assessment in Health Care, 2009
The Republic of Singapore is an island city-state in Southeast Asia. Its population enjoys good health and the Singapore Ministry of Health's mission is to promote good health and reduce illness, ensure access to good and affordable health care, and pursue medical excellence.
openaire   +2 more sources

Assessing the learning curve effect in health technologies: Lessons from the non-clinical literature [PDF]

, 2002
Introduction: Many health technologies exhibit some form of learning effect, and this represents a barrier to rigorous assessment. It has been shown that the statistical methods used are relatively crude.
Garthwaite, Paul H., Grant, Adrian M., Monk, Andrew F., Ramsay, Craig R., Russell, Ian T., Wallace, Sheila A.   +5 more
core  

Comprehensive assessment of complex technologies: integrating various aspects in health technology assessment [PDF]

, 2017
Objectives: Despite recent development of health technology assessment (HTA) methods, there are still methodological gaps for the assessment of complex health technologies.
Bjørn Hofmann, Jacob Burns, James B. Chilcott, Jan Benedikt Brönneke, Kati Mozygemba, Kristensen, Kristin Bakke Lysdahl, Lysdahl, Sue Ward   +8 more
core   +1 more source