Results 101 to 110 of about 23,885,267 (262)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Protocol for a health technology assessment of extending BowelScreen to those aged 50 to 54 years
Following a request from the National Screening Advisory Committee (NSAC), HIQA has commenced work on a health technology assessment (HTA) of extending Ireland’s national colorectal cancer screening programme, BowelScreen, to those aged 50 to 54 years ...
Health Information and Quality Authority (HIQA)
core
Office of Technology Assessment List of Publications, January 1993
, 1993 A catalog of Office of Technology Assessment (OTA) documents published through ...
Office of Technology Assessment
core
The Implications of Cost-Effectiveness Analysis of Medical Technology [PDF]
, 1980 A case study by the Office of Technology Assessment (OTA) that "touches on only some of the aspects of technology assessment that might be undertaken with respect to multichannel chemistry analyzers" (p. 7)
United States. Congress. Office of Technology Assessment.
core
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Office of Technology Assessment List of Publications, September 1985
, 1985 A catalog of Office of Technology Assessment (OTA) documents published through ...
Office of Technology Assessment
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Respiratory syncytial virus (RSV) is a virus that infects the lungs and upper airways. This virus spreads every winter, with the RSV season in Ireland typically running from October to March.
Health Information and Quality Authority (HIQA)
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
, 1983 A case study by the Office of Technology Assessment (OTA) that examines "the evidence on variations in lengths of hospital stay and their relation to health outcomes" (p. 3)
United States. Congress. Office of Technology Assessment.
core