Results 81 to 90 of about 979,842 (317)

VP66 Perception Of Decision Makers And Researchers Towards Health Technology Assessment In Ghana

, 2022
INTRODUCTION:In recent years, the Ghana health system has been faced with the challenge of financial sustainability. New ways of making decisions in a cost-effective manner that ensure efficient use of available resources is being explored. Consequently,
Hall, J, Haas, M, Addo, R, Goodall, S
core   +1 more source

Comparative analysis of breast cancer care models and patient journeys across six European countries: implications for the Austrian healthcare system

BMC Health Services Research
Introduction The increasing prevalence of breast cancer is straining hospital-centred healthcare systems worldwide, including Austria’s. This study examined breast cancer care models across six European countries to identify alternative approaches for ...
Nicole Grössmann-Waniek, Michaela Riegelnegg, Claudia Wild, Christoph Strohmaier   +3 more
doaj   +1 more source

Lipoedema research priorities: a Swedish priority-setting partnership for future treatment and diagnostic studies

BMJ Open
Objectives To identify research priorities related to the diagnosis, treatment and management of lipoedema.Design This was a research question priority-setting that ensured the involvement of patients, relatives and healthcare professionals in all parts.
Sara Fundell, Johan Dahlberg, Marie Österberg, Christel Hellberg, Jenny Stenman, Åsa G Andersson, Silvia Edling, Anders Liss   +7 more
doaj   +1 more source

Relational continuity may give better clinical outcomes in patients with serious mental illness – a systematic review

BMC Psychiatry, 2023
Background Continuity of care is considered important for results of treatment of serious mental illness (SMI). Yet, evidence of associations between relational continuity and different medical and social outcomes is sparse.
Ingemar Engström, Lars Hansson, Lilas Ali, Jenny Berg, Mirjam Ekstedt, Sven Engström, Maja Kärrman Fredriksson, Jan Liliemark, Per Lytsy   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparative Effectiveness and Safety of Allografts and Autografts in Posterior Cruciate Ligament Reconstruction Surgery: A Systematic Review

Arthroscopy, Sports Medicine, and Rehabilitation, 2020
Purpose: To evaluate the evidence of the effectiveness and safety of allografts compared to autografts in posterior cruciate ligament reconstruction.
Cecilia de Villiers, M.Sc., B.Sc., Gregor Goetz, M.S.Sc., M.P.H., Patrick Sadoghi, M.D., Ph.D., M.B.A., Sabine Geiger-Gritsch, D.M.Sc., M.H.Sc., M.Pharm   +3 more
doaj   +1 more source

Health technology assessment in Europe [PDF]

Scandinavian Journal of Public Health, 2009
Many European countries use health technology assessment (HTA) to assist in making decisions and policies in the health field, and public health and medical decision makers in Europe are now formally building HTA into certain policy, governance, reimbursement, or regulatory processes.
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Models and applications for measuring the impact of health research: update of a systematic review for the Health Technology Assessment programme [PDF]

, 2016
Background: This report reviews approaches and tools for measuring the impact of research programmes, building on, and extending, a 2007 review.Objectives: (1) To identify the range of theoretical models and empirical approaches for measuring the impact ...
Matthew Glover, Amanda Blatch-Jones, Greenhalgh, T, Hanney, S, Raftery, James, Blotch-Jones, A., Glover, Matthew, Glover, M, Blatch-Jones, Amanda, Raftery, J, Hanney, Steve, Hanley, S., James Raftery, Trish Greenhalgh, Greenhalgh, Trish, Blatch-Jones, A, Raftery, J., Glover, M., Blatch-Jones, Amanda Jane, Steve Hanney   +19 more
core   +1 more source