Results 161 to 170 of about 13,430,401 (352)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Correlates of Gambling Behaviour Among Adolescents: The Role of Psychological Factors, School Behaviours, and Normative Perceptions

Behavioral Sciences
Background: Gambling risk behaviour is an emerging problem among adolescents. This study investigated the role of psychological factors, school behaviours, and normative perceptions as correlates of gambling among 12–14-year-old students in Italy ...
Mariaelisa Renna, Emina Mehanović, Giulia Giraudi, Alberto Sciutto, Erica Viola, Marco Martorana, Serena Vadrucci, Maria Ginechesi, Claudia Vullo, Adalgisa Ceccano, Chiara Andrà, Pietro Casella, Fabrizio Faggiano, Federica Vigna-Taglianti, the GAPUnplugged Coordination Group   +14 more
doaj   +1 more source

Forecasting the Health Transition and Medical Expenditure of the Future Elderly in China: A Longitudinal Study Based on Markov Chain and Two Part Model. [PDF]

Front Public Health, 2021
Gao Y, Li J, Yuan X.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Diagnostic accuracy of non-invasive SARS-CoV-2 screening tests: a national prospective analysis

BMC Infectious Diseases
Background Providing non-invasive, accurate and affordable SARS-CoV-2 tests represents a public health priority, to better control the spread of the virus while protecting healthcare workers.
Thomas Althaus, Alexandre Blake, Alizée Costantini, Christian Lavagna, Eva Jacquesson, Guillaume Groshenry, Alexa Troel, Bertrand Vanzo, Olivier Dejoux, Hervé Raps, Patrick Rampal, Eric J. Voiglio   +11 more
doaj   +1 more source

Connected by 25: Effective Policy Solutions for Vulnerable Youth Issue Brief [PDF]

, 2010
In an effort to strengthen philanthropic investments among its membership, the Youth Transition Funders Group (YTFG) asked a group of policy experts to provide recommendations on how foundations can work to encourage effective policy solutions on issues ...

core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Age transition of tuberculosis incidence and mortality in Brazil

Revista de Saúde Pública
OBJECTIVE: Before the Aids pandemic, demographic transition and control programs prompted a shift in the age of incidence of tuberculosis from adults to older people in many countries.
Flávio Chaimowicz
doaj  

The impact of the health microinsurance M-FUND on the utilization of health services among migrant workers and their dependents in Thailand: A case-control study

Journal of Migration and Health
Background: Even though Thailand has launched multiple migrant health policies, migrants still face various barriers in accessing health care. To some extent, these barriers may be reduced by health microinsurance.
Andrea König, Jarntrah Sappayabanphot, Li Liang, Steffen Fleßa, Volker Winkler   +4 more
doaj   +1 more source