Results 51 to 60 of about 12,434,895 (247)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A longitudinal study of heatwave-health vulnerability in Australia [PDF]
Heatwave is an increasing threat to public health in Australia. However, the extent of spatiotemporal variations in heatwave-health vulnerability across Australia is still unclear.
Phung, Dung +4 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Poverty and Vulnerability - An Interdisciplinary Approach [PDF]
This paper describes the concepts of poverty and vulnerability as well as the interconnections and differences between them using an interdisciplinary approach. While poverty is a static concept, vulnerability has a forward-looking dimension.
Makoka, Donald, Kaplan, Marcus
core
Populations Vulnérables, 2017 À partir d’une démarche d’anthropologie pratique initiée par le cabinet Anthropos, cet article rend compte d’éléments d’analyse des situations de vulnérabilité en santé de travailleurs migrants âgés vivant en habitat social adapté (foyer ou résidence ...
Adrienne O’Deye +3 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Vulnerability and public service delivery in China from 1985 to 1999 [PDF]
This research focused on the determinants of vulnerability, as measured by the variable of expenditure on food consumption, by the quality of public service delivery as measured by three education variables (amount of students per teacher in primary ...
Mary-Françoise RENARD, Richard SCHIERE
core
Revista Enfermagem UERJ, 2015 A família é influenciada por fatores de ordem social, cultural, econômica, política, determinando transformações em sua configuração e dinâmica.
Joana Iabrudi Carinhanha +2 more
doaj +2 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source