Results 61 to 70 of about 12,434,895 (247)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Revista Enfermagem UERJ, 2013 Este estudo teve por objetivo analisar as representações sociais elaboradas por enfermeiros acerca de sua vulnerabilidade nas relações interpessoais mantidas com pacientes que vivem com HIV/AIDS.
Érick Igor dos Santos +3 more
doaj +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Methods for microeconometric risk and vulnerability assessments [PDF]
This"toolkit"provides quantitative tools to practitioners who want to undertake risk and vulnerability assessments using household data. While one could use price, exchange rate, and balance of payments data to examine macroeconomic shocks, and rainfall ...
Hoddinott, John, Quisumbing, Agnes
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Climate Change and health: vulnerability pathways and resilience policies
MedwaveClimate change is a serious threat to public health. The intensity and devastation of 21st-century climate events exacerbate the vulnerability of certain social groups that already face historical disadvantages.
Mónica Izurieta-Guevara +3 more
doaj +1 more source
Analysis of the sexual exposure trends to human immunodeficiency virus
DST, 2022 Introduction: In Brazil, approximately 60% of cases of acquired immunodeficiency syndrome (AIDS) are associated with some form of sexual contact, of which almost half are due to unprotected sex between men who have sex with men.
João Márcio Nunes de Alencar +6 more
doaj