Results 81 to 90 of about 12,434,895 (247)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Vulnerability to Poverty: A Microeconometric Approach and Application to the Republic of Haiti [PDF]

This paper investigates vulnerability to poverty in Haiti. Research in vulnerability in developing countries has been scarce due to the high data requirements of vulnerability studies (e.g. panel or long series of cross-sections). The methodology adopted
Evans Jadotte
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Atendimento pré-natal na ótica de puérperas: da medicalização à fragmentação do cuidado

Revista da Escola de Enfermagem da USP
Este estudo qualitativo e exploratório-descritivo objetivou conhecer a percepção de puerpéras sobre atendimento em serviço de pré-natal. Os dados coletados mediante entrevista semiestruturada foram submetidos à análise temática, tendo por sujeitos oito ...
Fernanda Beheregaray Cabral, Leila Maria Hirt, Isabel Cristina Pacheco Van der Sand   +2 more
doaj  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

IRON DEFICIENCY ANEMIA AND ITS RELATIONSHIP WITH SOCIOECONOMIC VULNERABILITY

Revista Paulista de Pediatria
Objective: To analyze the association of anemia with the socioeconomic vulnerability of preschoolers in public day care centers, in the city of Taubaté, SP, Brazil. Methods: This is a cross-sectional study with a probabilistic sample that analyzed 363
Élida Mara Braga Rocha, Amanda Forster Lopes, Silvia Maira Pereira, Claudio Leone, Luiz Carlos de Abreu, Patricia Dore Vieira, Sophia Cornbluth Szarfarc   +6 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Intersecting paths: Vulnerability, Gender, and Migration. Mental health implications for migrant women in Latin America. [PDF]

openThis thesis critically examines the intersecting dimensions of vulnerability, gender, and migration within Latin America, focusing on the mental health implications for migrant women. With a particular emphasis on Venezuelan migrants and the perilous
DOMINGUEZ JAEN, FADUA GISELL
core  

Integrity of white matter structure is related to episodic memory performance in the low-educated elderly

Arquivos de Neuro-Psiquiatria
The low-educated elderly are a vulnerable population in whom studying the role of white matter integrity on memory may provide insights for understanding how memory declines with aging and disease.
Elisa de Paula França Resende, Fernanda Freire Tovar-Moll, Fernanda Meireles Ferreira, Ivanei Bramati, Leonardo Cruz de Souza, Karoline Carvalho Carmona, Henrique Cerqueira Guimarães, Viviane Amaral Carvalho, Maira Tonidandel Barbosa, Paulo Caramelli   +9 more
doaj   +1 more source