Results 51 to 60 of about 386,216 (305)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Interpreters and cultural mediators – different but complementary roles [PDF]

, 2010
This article considers the roles of medical interpreters and cultural mediators and proposes that the two should be seen as separate. In the last six years cultural mediators have been trained in Ireland not to be interpreters but to help immigrants from
Martín, Mayte, Phelan, Mary
core  

????????? ?????? ???????????? ?????? ???????????? ?????? ??????????????? ???????????? ????????? ???????????? ?????? [PDF]

, 2020
Department of Computer Science and EngineeringAs deep learning has grown fast, so did the desire to interpret deep learning black boxes. As a result, many analysis tools have emerged to interpret it.
Lee, Ginkyeng
core  

A care pathway approach to identifying factors that impact on diagnosis of heart disease in British Pakistani women [PDF]

, 2013
Purpose – The authors examined the cardiac care pathway with the aim of identifying factors that impact on diagnosis and treatment of coronary heart disease in British Pakistani women.
Chowbey, Punita, Dhoot, Parmjeet, Piercy, Hilary, Salway, Sarah, Soady, John, Willis, Lerleen   +5 more
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

An Interactional Perspective on Interpreting as Mediation

Lingue Culture Mediazioni, 2015
The importance of mediation in dialogue interpreting has been highlighted in a number of recent studies. Franz Pöchhacker has outlined three analytical dimensions to look at interpreting as mediation: (1) linguistic/cultural mediation, including ...
Claudio Baraldi
doaj   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Patient Safety, Professionalization, and Reimbursement as Primary Drivers for National Medical Interpreter Certification in the United States

Translation and Interpreting : the International Journal of Translation and Interpreting Research, 2013
In a medical setting, interpretation by unskilled bilingual individuals can have serious repercussions when it results in a lower standard of care for minority-language patients.
Izabel S. Arocha, Linda Joyce
doaj  

Interpreting for Ukrainian refugees in the healthcare system in Poland

Stridon
The war in Ukraine has led to a surge in migration across Europe, particularly to Poland. De­spite the urgent need for effective integration infrastructure, the Polish government was unable to provide adequate reception services for refugees.
Małgorzata Tryuk
doaj   +1 more source