Results 31 to 40 of about 429,551 (311)

Functional dedifferentiation of associative resting state networks in older adults – A longitudinal study

open access: yesNeuroImage, 2020
Healthy aging is associated with weaker functional connectivity within resting state brain networks and stronger functional interaction between these networks.
Brigitta Malagurski   +4 more
doaj   +1 more source

Expanding the agenda for research on the physically active aging body [PDF]

open access: yes, 2009
In this article, the authors consider the different approaches that can be used to examine the relationship between physical activity and aging. They propose that much is to be gained in our awareness of this dynamic relationship by drawing on multiple ...
Phoenix, Cassandra   +5 more
core   +1 more source

Heterogeneity in Healthy Aging [PDF]

open access: yesThe Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013
For a surprisingly large segment of the older population, chronological age is not a relevant marker for understanding, measuring, or experiencing healthy aging. Using the 2003 Medical Expenditure Panel Survey and the 2004 Health and Retirement Study to examine the proportion of Americans exhibiting five markers of health and the variation in health ...
David J, Lowsky   +3 more
openaire   +2 more sources

Regional distribution of white matter hyperintensities in vascular dementia, Alzheimer's disease and healthy aging [PDF]

open access: yes, 2004
Background: White matter hyperintensities (WMH) on MRI scans indicate lesions of the subcortical fiber system. The regional distribution of WMH may be related to their pathophysiology and clinical effect in vascular dementia (VaD), Alzheimer's disease ...
Zebuhr, Y   +20 more
core   +1 more source

Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity

open access: yesMolecules, 2018
Non-alcoholic fatty liver disease (NAFLD) as a global health problem has clinical manifestations ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and cancer.
Lu-Min Shih   +5 more
doaj   +1 more source

Contributions of Dickkopf‐1 to Obesity‐Induced Bone Loss and Marrow Adiposity

open access: yesJBMR Plus, 2020
Low bone strength in overweight individuals is a significant medical problem. One important determinant of mesenchymal stem cell fate into osteoblasts or adipocytes is the Wnt signaling pathway.
Juliane Colditz   +3 more
doaj   +1 more source

Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

open access: yesFrontiers in Physiology, 2017
Introduction/Purpose: A number of studies have investigated the effect of training with a moderate exercise dose (3–6 h/weekly) on the inflammatory profile in blood, and the data are inconsistent.
Ronni E. Sahl   +10 more
doaj   +1 more source

Object-Location Memory Training in Older Adults Leads to Greater Deactivation of the Dorsal Default Mode Network

open access: yesFrontiers in Human Neuroscience, 2021
Substantial evidence indicates that cognitive training can be efficacious for older adults, but findings regarding training-related brain plasticity have been mixed and vary depending on the imaging modality.
Ania Mikos   +5 more
doaj   +1 more source

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

open access: yesCell Death and Disease, 2022
Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes to the development of tumor suppressive immune microenvironment and
Lin Zhao   +6 more
doaj   +1 more source

A New Strategic Approach to Successful Aging and Healthy Aging [PDF]

open access: yes, 2018
Successful aging is not a new concept, although its definition remains controversial, because of its multi-dimensional nature.
Roger Y. Wong, Roger Y. Wong
core   +1 more source

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