Results 31 to 40 of about 960,492 (356)

Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity

open access: yesMolecules, 2018
Non-alcoholic fatty liver disease (NAFLD) as a global health problem has clinical manifestations ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and cancer.
Lu-Min Shih   +5 more
doaj   +1 more source

Object-Location Memory Training in Older Adults Leads to Greater Deactivation of the Dorsal Default Mode Network

open access: yesFrontiers in Human Neuroscience, 2021
Substantial evidence indicates that cognitive training can be efficacious for older adults, but findings regarding training-related brain plasticity have been mixed and vary depending on the imaging modality.
Ania Mikos   +5 more
doaj   +1 more source

Repeated Excessive Exercise Attenuates the Anti-Inflammatory Effects of Exercise in Older Men

open access: yesFrontiers in Physiology, 2017
Introduction/Purpose: A number of studies have investigated the effect of training with a moderate exercise dose (3–6 h/weekly) on the inflammatory profile in blood, and the data are inconsistent.
Ronni E. Sahl   +10 more
doaj   +1 more source

Contributions of Dickkopf‐1 to Obesity‐Induced Bone Loss and Marrow Adiposity

open access: yesJBMR Plus, 2020
Low bone strength in overweight individuals is a significant medical problem. One important determinant of mesenchymal stem cell fate into osteoblasts or adipocytes is the Wnt signaling pathway.
Juliane Colditz   +3 more
doaj   +1 more source

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer

open access: yesCell Death and Disease, 2022
Metabolic disorders and abnormal immune function changes occur in tumor tissues and cells to varying degrees. There is increasing evidence that reprogrammed energy metabolism contributes to the development of tumor suppressive immune microenvironment and
Lin Zhao   +6 more
doaj   +1 more source

Aging and decision making: a comparison between neurologically healthy elderly and young individuals [PDF]

open access: yes, 2005
We report the results of experiments on economic decisions with two populations, one of healthy elderly individuals (average age 82) and one of younger students (average age 20).
Allman, John M.   +4 more
core   +1 more source

7-Ketocholesterol Induces Lipid Metabolic Reprogramming and Enhances Cholesterol Ester Accumulation in Cardiac Cells

open access: yesCells, 2021
7-Ketocholesterol (7KCh) is a major oxidized cholesterol product abundant in lipoprotein deposits and atherosclerotic plaques. Our previous study has shown that 7KCh accumulates in erythrocytes of heart failure patients, and further investigation ...
Mei-Ling Cheng   +6 more
doaj   +1 more source

The effects of healthy aging, amnestic mild cognitive impairment, and Alzheimer's disease on recollection, familiarity and false recognition, estimated by an associative process-dissociation recognition procedure [PDF]

open access: yes, 2016
Given the uneven experimental results in the literature regarding whether or not familiarity declines with healthy aging and cognitive impairment, we compare four samples (healthy young people, healthy older people, older people with amnestic mild ...
Abe   +57 more
core   +2 more sources

Calcium Binding Mechanism of Soybean Peptide with Histidine Alteration by Molecular Docking Analysis and Spectroscopic Methods

open access: yesFoods, 2022
Histidine (His) carries a unique heteroaromatic imidazole side chain and plays an irreplaceable role in peptides and proteins. With the current study, we aimed to determine the characteristics and functional activities of the bone density of soy peptide ...
Jing Gan   +8 more
doaj   +1 more source

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