Results 11 to 20 of about 403,438 (266)
Healthy ageing and spermatogenesis [PDF]
Reproduction, 2021 Abstract Delayed family planning and increased parental age increase the risk for infertility and impaired offspring health. While the impact of ageing on oogenesis is well studied, this is less understood on spermatogenesis. Assessing ageing effects on the male germline presents a challenge in differentiating between the effects of ...
Eva, Pohl +3 more
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Scientific Reports, 2021 Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2 SNP = 0.12) and were highly genetically
Heidi Foo +6 more
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Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Cell Death and Disease, 2023 Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways.
Laura Ryder +8 more
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Healthy Aging as Disease? [PDF]
Frontiers in Aging Neuroscience, 2011 In the scientific and popular literature recently there has been a widespread call for classifying normal aging as a disease, a condition that can be “manipulated, treated, and delayed” (Gems, 2010; Kelland, 2010). The main argument given by supporters of this suggestion is that grant-awarding bodies would be more likely to fund research into how, when,
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Protein and healthy aging [PDF]
The American Journal of Clinical Nutrition, 2015 Our understanding of the potential benefits and challenges of optimizing dietary protein intake in older adults continues to evolve. An overarching hypothesis generated during Protein Summit 2.0 was that consuming an adequate amount of high-quality protein at each meal, in combination with physical activity, may delay the onset of sarcopenia, slow its ...
Paddon-Jones, Douglas +6 more
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Skeletal endocrinology: where evolutionary advantage meets disease
Bone Research, 2021 The regulation of whole-body homeostasis by the skeleton is mediated by its capacity to secrete endocrine signaling molecules. Although bone-derived hormones confer several adaptive benefits, their physiological functions also involve trade-offs, thus ...
Nikolai Jaschke +4 more
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Healthy ageing: ageing safely [PDF]
European Heart Journal Supplements, 2001 The population of the developed world is steadily ageing. In the European Union, approximately 22% of persons are over 60 years of age and this is projected to increase to more than 27% by the year 2020. This has major implications for health care resources and the productive workforce. Ageing is accompanied by a decline in the physiological reserve of
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NeuroImage, 2020 Healthy aging is associated with weaker functional connectivity within resting state brain networks and stronger functional interaction between these networks.
Brigitta Malagurski +4 more
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Heterogeneity in Healthy Aging [PDF]
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2013 For a surprisingly large segment of the older population, chronological age is not a relevant marker for understanding, measuring, or experiencing healthy aging. Using the 2003 Medical Expenditure Panel Survey and the 2004 Health and Retirement Study to examine the proportion of Americans exhibiting five markers of health and the variation in health ...
David J, Lowsky +3 more
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