Results 11 to 20 of about 960,492 (356)
Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia
BMC Geriatrics, 2023 Background Sarcopenia is defined as the disease of muscle loss and dysfunction. The prevalence of sarcopenia is strongly age-dependent. It could bring about disability, hospitalization, and mortality.
Chi-Jen Lo +6 more
doaj +1 more source
Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly
Nature Communications, 2022 Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that are essential for alpha-synuclein aggregation and test ...
Jemil Ahmed +12 more
doaj +1 more source
Separations, 2023 Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and ...
Jiwei Yang +10 more
doaj +1 more source
BMC Public Health, 2023 Background As the older population increases, the need for early detection of cognitive decline is also increasing. In this study, we examined whether our paper–pencil type group examination for cognitive assessment (PAPLICA) could detect the effects of ...
Daisuke Cho +10 more
doaj +1 more source
Scientific Reports, 2021 Type 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has been found to be increased in the serum of patients with T1DM.
Nick Hildebrandt +7 more
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Scientific Reports, 2021 Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44–80 years). The eighteen measures studied showed low heritability (mean h2 SNP = 0.12) and were highly genetically
Heidi Foo +6 more
doaj +1 more source
Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms
Cell Death and Disease, 2023 Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways.
Laura Ryder +8 more
doaj +1 more source
Differential genetic advantages in youth and in aging, or how to die healthy [PDF]
, 2012 Human society ages at a steady rate, that is, the proportion of adult and elderly individuals increases constantly because of improved living conditions and the advances in medical care.
Khalil, Hilal S. +2 more
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Healthy Aging as Disease? [PDF]
Frontiers in Aging Neuroscience, 2011 In the scientific and popular literature recently there has been a widespread call for classifying normal aging as a disease, a condition that can be “manipulated, treated, and delayed” (Gems, 2010; Kelland, 2010). The main argument given by supporters of this suggestion is that grant-awarding bodies would be more likely to fund research into how, when,
openaire +3 more sources