Results 1 to 10 of about 403,438 (266)

Prevalence and Trends of Slow Gait Speed in the United States

open access: yesGeriatrics, 2023
Gait speed is a simple, effective indicator of age-related disease and disability. We sought to examine the prevalence and trends of slow gait speed in older Americans.
Emily Stover   +8 more
doaj   +1 more source

Identification of KIFC1 as an independent prognostic marker in renal clear cell carcinoma correlates with tumor proliferation and immune infiltration

open access: yesScientific Reports, 2023
Renal clear cell carcinoma (ccRCC) is the world's most common form of cancer. Up to a third will develop metastases; the 5-year survival rate of the patients was only 14%. Practical prognostic markers remain to be discovered. Kinesin-like protein (KIFC1),
Bin Du   +4 more
doaj   +1 more source

A multiplex chemiluminescent immunoassay for serological profiling of COVID-19-positive symptomatic and asymptomatic patients

open access: yesNature Communications, 2021
Antibody responses to SARS-CoV-2 may be important biomarkers for assessing the risk for viral transmission. Here the authors present serological antibody profiling results of COVID-19 patients using a new multiplex assay to show distinct kinetics and ...
Allison N. Grossberg   +7 more
doaj   +1 more source

Neuroticism, physical activity, and cognitive functioning in a population-based cohort of older adults

open access: yesBMC Geriatrics, 2023
Background Little is known about how physical activity influences the relationship between neuroticism and cognitive function and cognitive decline. Methods Data from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is
Pankaja Desai   +5 more
doaj   +1 more source

Perceptions of older adults and generativity among older citizens in Japan: a descriptive cross-sectional study [PDF]

open access: yesOsong Public Health and Research Perspectives, 2023
Objectives As the population ages worldwide, including in Japan, there is a growing expectation for older adults to remain active participants in society.
Yuho Shimizu   +11 more
doaj   +1 more source

Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia

open access: yesBMC Geriatrics, 2023
Background Sarcopenia is defined as the disease of muscle loss and dysfunction. The prevalence of sarcopenia is strongly age-dependent. It could bring about disability, hospitalization, and mortality.
Chi-Jen Lo   +6 more
doaj   +1 more source

Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly

open access: yesNature Communications, 2022
Inhibiting alpha-synuclein self-assembly into amyloid structures, associated with Parkinson’s disease, is a potential therapeutic intervention. Here, the authors identify the domains/sequences that are essential for alpha-synuclein aggregation and test ...
Jemil Ahmed   +12 more
doaj   +1 more source

Green Extraction of Phenolic Compounds from Lotus (Nelumbo nucifera Gaertn) Leaf Using Deep Eutectic Solvents: Process Optimization and Antioxidant Activity

open access: yesSeparations, 2023
Natural deep eutectic solvents (NDESs) were used to extract flavonoids and polyphenols from lotus (Nelumbo nucifera Gaertn.) leaves at the same time, and the extraction process was optimized to provide reference for the effective development and ...
Jiwei Yang   +10 more
doaj   +1 more source

Evaluation of the usefulness of a paper–pencil group cognitive assessment for older adults in the community

open access: yesBMC Public Health, 2023
Background As the older population increases, the need for early detection of cognitive decline is also increasing. In this study, we examined whether our paper–pencil type group examination for cognitive assessment (PAPLICA) could detect the effects of ...
Daisuke Cho   +10 more
doaj   +1 more source

Role of osteogenic Dickkopf-1 in bone remodeling and bone healing in mice with type I diabetes mellitus

open access: yesScientific Reports, 2021
Type 1 diabetes mellitus (T1DM) is associated with low bone mass and a higher risk for fractures. Dickkopf-1 (Dkk1), which inhibits Wnt signaling, osteoblast function, and bone formation, has been found to be increased in the serum of patients with T1DM.
Nick Hildebrandt   +7 more
doaj   +1 more source

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