Results 61 to 70 of about 960,492 (356)

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles, Cararo-Lopes, Marina Minto, Kawamoto, Elisa Mitiko, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo   +4 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Unraveling the independent role of METTL3 in m6A modification and tumor progression in esophageal squamous cell carcinoma

Scientific Reports
METTL3 and METTL14 are traditionally posited to assemble the m6A methyltransferase complex in a stoichiometric 1:1 ratio, modulating mRNA fate via m6A modifications. Nevertheless, recent investigations reveal inconsistent expression levels and prognostic
Bin Du, Pu Wang, Lingyu Wei, Kai Qin, Zhen Pei, Jinping Zheng, Jia Wang   +6 more
doaj   +1 more source

Understanding the Role of Oxidative Stress in Platelet Alterations and Thrombosis Risk among Frail Older Adults

Biomedicines
Frailty and cardiovascular diseases are increasingly prevalent in aging populations, sharing common pathological mechanisms, such as oxidative stress. The evidence shows that these factors predispose frail individuals to cardiovascular diseases but also ...
Diego Arauna, Simón Navarrete, Cecilia Albala, Sergio Wehinger, Rafael Pizarro-Mena, Iván Palomo, Eduardo Fuentes   +6 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

iScience, 2022
Summary: Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance.
Zhifen Zhou, Yujing Li, Huimin Xu, Xiaowei Xie, Zibin He, Song Lin, Ruofei Li, Shouheng Jin, Jun Cui, Hai Hu, Feng Liu, Su Wu, Wenbin Ma, Zhou Songyang   +13 more
doaj   +1 more source

Understanding the role of contrasting urban contexts in healthy aging: an international cohort study using wearable sensor devices (the CURHA study protocol). [PDF]

, 2016
BACKGROUND: Given the challenges of aging populations, calls have been issued for more sustainable urban re-development and implementation of local solutions to address global environmental and healthy aging issues.
Alexandre Naud, Basile Chaix, Benoit Thierry, Bernhard Köppen, Cédric Sueur, Hélène Payette, Julie Vallée, Lise Gauvin, Lucie Richard, Marion Patte, Martine Shareck, Michel Desprès, Olivier Klein, Philippe Gerber, Pierre Rondier, Rania Wasfi, Sylvain Klein, Sébastien Lord, Yan Kestens   +18 more
core   +4 more sources

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link? [PDF]

, 2020
Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress.
Erusalimsky, Jorge
core   +1 more source

HEALTHY AGING AND OLDER ADULTS WITH AUTISM: A SCOPING REVIEW [PDF]

, 2023
Mary Stringfellow, Noelle Fields, Kathy Lee, Keith A. Anderson   +3 more
openalex   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source