Results 61 to 70 of about 429,551 (311)

Digitally Inclusive, Healthy Aging Communities (DIHAC): A Cross-Cultural Study in Japan, Republic of Korea, Singapore, and Thailand [PDF]

, 2022
One out of three people in Japan will be an older person before 2040. Half of those currently do not utilize the internet, smartphone apps, or digital technology.
Kumiko Nonaka, Moolphate, Saiyud, Cheung, Paul, Field, Malcolm, Myat Yadana Kyaw, Motoyuki Yuasa, Koyanagi, Yuka, Yuka Koyanagi, Malcolm Field, Aung, Myo Nyein, Nagamine, Yuiko, Nam, Eun Woo, Kyaw, Myat Yadana, Paul Cheung, Nonaka, Kumiko, Saiyud Moolphate, Shirayama, Yoshihisa, Yuiko Nagamine, Nadila Mulati, Mulati, Nadila, Eun Woo Nam, Yoshihisa Shirayama, Yuasa, Motoyuki, Myo Nyein Aung   +23 more
core   +1 more source

Unraveling the independent role of METTL3 in m6A modification and tumor progression in esophageal squamous cell carcinoma

Scientific Reports
METTL3 and METTL14 are traditionally posited to assemble the m6A methyltransferase complex in a stoichiometric 1:1 ratio, modulating mRNA fate via m6A modifications. Nevertheless, recent investigations reveal inconsistent expression levels and prognostic
Bin Du, Pu Wang, Lingyu Wei, Kai Qin, Zhen Pei, Jinping Zheng, Jia Wang   +6 more
doaj   +1 more source

The German version of the Mini Suffering State Examination (MSSE) for people with advanced dementia living in nursing homes

BMC Geriatrics, 2022
Background The Mini Suffering State Examination (MSSE) has been explicitly recommended to assess suffering in dementia patients. This study aimed to develop a German version of the MSSE and assess its psychometric properties involving people with ...
Naomi Zumstein, Keiko Yamada, Stefanie Eicher, Nathan Theill, Heike Geschwindner, Henrike Wolf, Florian Riese   +6 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

White matter hyperintensity, neurofilament light chain, and cognitive decline

Annals of Clinical and Translational Neurology, 2023
Objective We aimed to determine whether combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition in older adults.
Anisa Dhana, Charles DeCarli, Klodian Dhana, Pankaja Desai, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan   +6 more
doaj   +1 more source

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase

iScience, 2022
Summary: Most tumor cells reactivate telomerase to ensure unlimited proliferation, whereas the expression of human telomerase reverse transcriptase (hTERT) is tightly regulated and rate-limiting for telomerase activity maintenance.
Zhifen Zhou, Yujing Li, Huimin Xu, Xiaowei Xie, Zibin He, Song Lin, Ruofei Li, Shouheng Jin, Jun Cui, Hai Hu, Feng Liu, Su Wu, Wenbin Ma, Zhou Songyang   +13 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Circadian Rhythm of Distal Skin Temperature in Healthy Older and Young Women and Its Relationship with Sleep–Wake Rhythm and Environmental Factors under Natural Living Conditions [PDF]

Little is known about the healthy aging of the circadian timing system under natural living conditions. This study explores changes in the circadian rhythm of distal skin temperature (DST) with aging and relates these changes to sleep–wake timing ...
Stefanie Wedell, Manuela Dittmar, Tina Stark   +2 more
core   +1 more source

Association of ART regimen and adherence to viral suppression: an observational study of a clinical population of people with HIV

AIDS Research and Therapy
Adherence to antiretroviral therapy (ART) is essential for the effective management of HIV, which includes keeping the HIV viral load undetectable. This study aimed to determine whether certain ART medications are more “forgiving” of poor adherence in ...
Jasmine A. Manalel, Jennifer E. Kaufman, Yiyi Wu, Ethan Fusaris, Arlene Correa, Jerome Ernst, Mark Brennan-Ing   +6 more
doaj   +1 more source

Lagged Coupled Changes Between White Matter Microstructure and Processing Speed in Healthy Aging: A Longitudinal Investigation

Frontiers in Aging Neuroscience, 2019
Age-related differences in white matter (WM) microstructure have been linked to lower performance in tasks of processing speed in healthy older individuals. However, only few studies have examined this link in a longitudinal setting. These investigations
Jessica Oschwald, Susan Mérillat, Franziskus Liem, Christina Röcke, Mike Martin, Mike Martin, Lutz Jäncke, Lutz Jäncke   +7 more
doaj   +1 more source