Results 81 to 90 of about 429,551 (311)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging [PDF]

, 2007
Brummelte S, Teuchert-Noodt G. Density of dopaminergic fibres in the prefrontal cortex of gerbils is sensitive to aging. Behavioral and Brain Functions.
Teuchert-Noodt, Gertraud, Susanne Brummelte, Gertraud Teuchert-Noodt, Brummelte, Susanne   +3 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Expression of TERT and Telomerase aactivity in the rat central nervous system during aging [PDF]

, 2010
The 5th International Symposium on Healthy Aging, Hong Kong, 6-7 March ...
Wu, G, Liu, M, Yip, HKF
core  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Cigarette smoking accelerated brain aging and induced alzheimer-like neurodegeneration in rats [PDF]

, 2012
The 7th International Symposium on Healthy Aging (ISHA 2012), Hong Kong, 3-4 March ...
Lau, CF, Ho, YS, Yang, XF, Yeung, SC, Tsang, AWT, Mak, JCW, Chang, RCC   +6 more
core  

The Wako Cohort Study: Design and Profile of Participants at Baseline

Journal of Epidemiology
Background: We launched the Wako Cohort Study in 2023 to identify individual and socio-environmental factors related to the extension of healthy life expectancy and the reduction of health disparities among community-dwelling adults and to develop health
Yuri Yokoyama, Yu Nofuji, Takumi Abe, Kumiko Nonaka, Yumi Ozone, Yuka Nakamura, Shiina Chiaki, Takumi Suda, Naoko Saito, Mai Takase, Hidenori Amano, Susumu Ogawa, Hiroyuki Suzuki, Hiroshi Murayama   +13 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

2018 Provincial consultations on healthy aging [PDF]

In 2018, the Coalition for Healthy Aging in Manitoba (CHAM) facilitated a series of workshops in various locations in Manitoba. Participants were asked to discuss what Manitoba is doing well and what could be improved with each of the following three ...
Coalition for Healthy Aging in Manitoba
core