Results 71 to 80 of about 960,492 (356)

The German version of the Mini Suffering State Examination (MSSE) for people with advanced dementia living in nursing homes

BMC Geriatrics, 2022
Background The Mini Suffering State Examination (MSSE) has been explicitly recommended to assess suffering in dementia patients. This study aimed to develop a German version of the MSSE and assess its psychometric properties involving people with ...
Naomi Zumstein, Keiko Yamada, Stefanie Eicher, Nathan Theill, Heike Geschwindner, Henrike Wolf, Florian Riese   +6 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Association of ART regimen and adherence to viral suppression: an observational study of a clinical population of people with HIV

AIDS Research and Therapy
Adherence to antiretroviral therapy (ART) is essential for the effective management of HIV, which includes keeping the HIV viral load undetectable. This study aimed to determine whether certain ART medications are more “forgiving” of poor adherence in ...
Jasmine A. Manalel, Jennifer E. Kaufman, Yiyi Wu, Ethan Fusaris, Arlene Correa, Jerome Ernst, Mark Brennan-Ing   +6 more
doaj   +1 more source

White matter hyperintensity, neurofilament light chain, and cognitive decline

Annals of Clinical and Translational Neurology, 2023
Objective We aimed to determine whether combining white matter hyperintensity (WMH) with neurofilament light chain (NfL) could provide additional information for cognition in older adults.
Anisa Dhana, Charles DeCarli, Klodian Dhana, Pankaja Desai, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan   +6 more
doaj   +1 more source

Synchrotron imaging assessment of bone quality [PDF]

, 2016
Bone is a complex hierarchical structure and its principal function is to resist mechanical forces and fracture. Bone strength depends not only on the quantity of bone tissue but also on the shape and hierarchical structure.
Abel, RL, Boughton, O, Cobb, JP, Hansen, U, Jin, A, Karunaratne, A, Ma, S   +6 more
core   +1 more source

Lagged Coupled Changes Between White Matter Microstructure and Processing Speed in Healthy Aging: A Longitudinal Investigation

Frontiers in Aging Neuroscience, 2019
Age-related differences in white matter (WM) microstructure have been linked to lower performance in tasks of processing speed in healthy older individuals. However, only few studies have examined this link in a longitudinal setting. These investigations
Jessica Oschwald, Susan Mérillat, Franziskus Liem, Christina Röcke, Mike Martin, Mike Martin, Lutz Jäncke, Lutz Jäncke   +7 more
doaj   +1 more source

Modafinil-Induced changes in functional connectivity in the cortex and cerebellum of healthy elderly subjects [PDF]

, 2017
In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals.
Caltagirone, Carlo, Gili, Tommaso, Petrosini, Laura, PUNZI, MIRIAM, SENSI, Stefano, Sensi, Stefano L., Spalletta, Gianfranco   +6 more
core   +3 more sources

ACTN3, Morbidity, and Healthy Aging [PDF]

Frontiers in Genetics, 2018
As human longevity increases, recent research has focused on the maintenance of optimal health during old age. One such area of focus is that of muscle function in the elderly, with a loss of muscle mass increasing the risk of negative outcomes such as sarcopenia and a decrease in bone mineral density.
Craig Pickering, Craig Pickering, John Kiely   +2 more
openaire   +4 more sources

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Dickkopf1 fuels inflammatory cytokine responses

Communications Biology, 2022
A combination of cell line, transgenic mouse and human genetic data implicates a proinflammatory function of Dickkopf1 across malignant and non-malignant cells.
Nikolai P. Jaschke, Sophie Pählig, Anupam Sinha, Timon E. Adolph, Maria Ledesma Colunga, Maura Hofmann, Andrew Wang, Sylvia Thiele, Julian Schwärzler, Alexander Kleymann, Marc Gentzel, Herbert Tilg, Ben Wielockx, Lorenz C. Hofbauer, Martina Rauner, Andy Göbel, Tilman D. Rachner   +16 more
doaj   +1 more source