Results 51 to 60 of about 565,874 (240)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Is Eating Raisins Healthy? [PDF]

Nutrients, 2019
Raisins are dried grapes consumed worldwide that contain beneficial components for human health. They are rich in fiber and phytochemicals such as phenolic compounds. Despite a 60% sugar content, several studies have reported health-promoting properties for raisins and this review compiles the intervention studies, as well as the cell line and animal ...
Alexandra Olmo-Cunillera, Danilo Escobar-Avello, Andy J. Pérez, María Marhuenda-Muñoz, Rosa Mª Lamuela-Raventós, Anna Vallverdú-Queralt   +5 more
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Organic school food policies are supportive for healthier eating behaviours – results from an observational study in Danish schools [PDF]

, 2010
Purpose – The purpose of this study was to examine whether organic food intervention strategies in Danish school meal systems can support the development of healthier eating patterns among pupils.
Chen, He, Løes, Anne-Kristin, Mikkelsen, Bent Egberg   +2 more
core  

Social marketing and healthy eating : Findings from young people in Greece [PDF]

, 2014
This document is the Accepted Manuscript version. The final publication is available at Springer via http://dx.doi.org/10.1007/s12208-013-0112-xGreece has high rates of obesity and non-communicable diseases owing to poor dietary choices.
A Bandura, A Carroll, A Drewnowski, A Kafatos, A Kirmani, A Papadaki, A Richards, A Thorpe, A Trichopoulou, AD Tsouros, Ariadne Beatrice Kapetanaki, Aristidis Daskalopoulos Foundation, B Dobson, B Popkin, B Sharma, B Smith, B Swinburn, C Domegan, C Hawkes, C Hawkes, C Lowe, D Silverman, David Ross Brennan, DB Panagiotakos, DG Carson, DJ Watts, E Shove, EH Asp, F Arvaniti, F Lagarde, G Dahlgren, G Hastings, G Hastings, G Hastings, G Hastings, G Hastings, G Hastings, GH Cohane, GR Niblett, H Walls, I Ajzen, I Contento, J Adams, J Aschemann-Witzel, J French, J Gregson, J Hoek, J Shepherd, JE Carins, JW Creswell, K Burchell, L Gracia-Marco, L Thornley, LJ Beasley, LJ Riddell, M Caraher, M Dooris, M Friestad, M Howlett, M Stead, M Stead, Martin Caraher, MN Fotiadou, N Lambert, N Robinson, NA Christakis, National Social Marketing Centre, NK Denzin, NK Janz, NR Luca, P Chandon, P Diamond, P Kotler, P Lagiou, P Wright, R Bagozzi, R Barbour, R Gordon, R Krueger, RC Lefebvre, RC Lefebvre, RC Lefebvre, RC Lefebvre, RC Lefebvre, RC Lefebvre, S Kirchhoff, SA Grier, T Jackson, T Lang, T Lang, T Psaltopoulou, TJ Harvey, W Wymer, W Wymer, WHO/Europe   +94 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source