Results 61 to 70 of about 113,372 (251)

Development of the Healthy Eating Index‐2010

The FASEB Journal, 2012
The Healthy Eating Index (HEI) is a measure of diet quality based on federal dietary guidance. Publication of the Dietary Guidelines for Americans, 2010 prompted an interagency working group to update the HEI‐2005 using the revised USDA Food Patterns.
Patricia M. Guenther, Kellie M. O'Connell, Jill Reedy, Sharon I. Kirkpatrick, Hazel A.B. Hiza, Kevin J. Kuczynski   +5 more
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Assessment of oral hygiene parameters in association to eating behaviors and healthy eating self-efficacy in school-aged children

BMC Oral Health
Background Eating behavior are a broad category influenced by a various personal, social, cultural, environmental, and economic factors. The objective of this study was to evaluate the oral hygiene status of school-aged children in relation to their ...
Seda Ceren Gökçek, Sabiha Ceren İlisulu   +1 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Association of The Healthy Eating Index and Body Composition Among Iran’s Paralympic Athletes with Hemodialysis and Hemophilia

Diyala Journal of Medicine, 2022
Background: Essential parameters of athletes that enhancing their fitness and success rate in sports career are body composition and anthropometric indices, additionally perfect performance of athletes with a prolonged and intensive season is ...
Thaer Easa Murad AL-Rubaye
doaj   +2 more sources

Index of healthy eating and emotional eating in relation to psychological inflexibility in dance students

Humanities & Social Sciences Communications
Dance places significant physical and cognitive demands on both students and professionals. These demands increase dancers’ susceptibility to a variety of problems.
Félix Arbinaga, María-Isabel Mendoza-Sierra, Gabriela Fernández-Acosta   +2 more
doaj   +1 more source

Relationship between primary school healthy eating and physical activity promoting environments and children’s dietary intake, physical activity and weight status: a longitudinal study in the West Midlands, UK

BMJ Open, 2020
Objective We aimed to examine the association between food and physical activity environments in primary schools and child anthropometric, healthy eating and physical activity measures.Design Observational longitudinal study using data from a childhood ...
Miranda Pallan, Peymane Adab, Joanne Clarke, Tania Griffin, Kiya Hurley, Alice J Sitch, Emma Lancashire, Sandra Passmore, Elizabeth Mairenn Garden   +8 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source