Results 241 to 250 of about 911,116 (309)

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Advanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li, Haifan Gong, Yue Wang, Yinuo Zhao, Lixiang Li, Peijing Bao, Qingzhou Kong, Jialu Fu, Boyao Wan, Yumeng Zhang, Jinghui Zhang, Jiekun Ni, Zhongxue Han, Xueping Nan, Kunping Ju, Longfei Sun, Yuerui Ma, Huijun Chang, Mengqi Zheng, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +23 more
wiley   +1 more source

Nutritional paradoxes of the new Dietary Guidelines for Americans (2025-2030): a critical analysis. [PDF]

J Bras Nefrol
Avesani CM, Cuppari L.
europepmc   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Association between dietary protein intake and frailty index among home-dwelling older adults; an 8-year follow-up study. [PDF]

J Nutr Health Aging
Bålsrud P, Ulven SM, Hjartåker A, Ottestad I, Retterstøl K, Schwab U, Christensen JJ, Thoresen M, Holven KB.   +8 more
europepmc   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Effects of M-Cube Wave Versus Low-Frequency Neuromuscular Electrical Stimulation on the Strength and Thickness of the Quadriceps Muscles: A Within-Subject Comparison in Healthy Young Adults. [PDF]

Cureus
Sato S, Nakamura M.
europepmc   +1 more source

The Influence of Early Gymnastic Exposure on the Triangular Fibrocartilage Complex in the Adolescent Wrist. [PDF]

J Hand Surg Glob Online
van der Post AS, Jens S, Kox LS, Obdeijn MC, Oostra RJ, Maas M.   +5 more
europepmc   +1 more source

A Clinician's Guide for Trending Cardiovascular Nutritional Controversies in 2026. [PDF]

JACC Adv
Miller M, Aggarwal M, Allen K, Bhattacharya R, Dastmalchi LN, Kris-Etherton PM, Klodas E, Mozaffarian D, Ostfeld RJ, Petersen KS, Reddy KR, Ros E, Vinaithirthan V, Freeman AM.   +13 more
europepmc   +1 more source

The association between liver fat content and plasma metabolite profiles in fasting and postprandial states: an integration of a cohort study and a randomized controlled trial. [PDF]

Cardiovasc Diabetol
Fang Y, de Mutsert R, Gijbels A, Deng K, Lamb H, Rosendaal FR, Mook-Kanamori DO, van Dijk KW, Afman LA, Li-Gao R.   +9 more
europepmc   +1 more source

Study on Age-Related Facial Fat Changes Using 3D MRI and a Novel Algorithm. [PDF]

Aesthet Surg J Open Forum
Sun M, Zhou Q, Wu Y, Hu J, Luo X, Lin X, Wang W, Zhou J, Zou C, Li Z.   +9 more
europepmc   +1 more source