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PIK3C3/VPS34 keeps body fats healthy

Autophagy, 2023
Adipose tissue, or body fat, plays a critical role in the maintenance of health and the development of metabolic diseases. The pathological expansion of adipose tissue during obesity and the pathological reduction of adipose tissue during lipodystrophy can lead to a similar array of metabolic diseases that include diabetes, but mechanisms remain to be ...
Wenqiang Song   +3 more
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Seipin: harvesting fat and keeping adipocytes healthy

Trends in Cell Biology, 2021
Seipin is a key protein in the assembly of cytoplasmic lipid droplets (cLDs) and their maintenance at endoplasmic reticulum (ER)-LD junctions; the absence of seipin results in generalized lipodystrophy. How seipin mediates LD dynamics and prevents lipodystrophy are not well understood.
Monala Jayaprakash, Rao, Joel M, Goodman
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Healthy fats and exclusion-zone size

Food Chemistry, 2020
A fourth phase of water, labeled exclusion-zone or "EZ," extends from hydrophilic surfaces. Salient features include exclusion of colloidal and molecular solutes, and characteristic light absorbance at 270 nm. In cell systems, EZ water interfaces with membranes, macromolecules, and organelles, and its buildup appears to be vital for function. For years
Abha Sharma, Gerald H. Pollack
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Fat, keeping the heart healthy?

Nature Medicine, 2005
The hormone adiponectin is secreted from fat cells and increases sensitivity to insulin in muscle and liver; adiponectin increases resistance to metabolic disorders and, it now appears, may also protect heart tissue when blood flow is restricted ( pages 1096–1103 ).
Koh-ichi Yuhki   +2 more
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