Results 131 to 140 of about 1,887,079 (308)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Living deep-water Lophelia and Madrepora corals in Maltese waters (Strait of Sicily, Mediterranean Sea) [PDF]
, 2007 The occurrence of living deep-water corals, Lophelia pertusa and Madrepora oculata, from stations 21-42 km off the southern and south-western coast of Malta is reported.
Camilleri, Matthew +3 more
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Predicting food insecurity among UK university students during the COVID-19 pandemic
Public Health NutritionObjective: The present study investigated potential predictors of food insecurity among UK university students during the COVID-19 pandemic. Design: Close-ended questionnaire administered to a cross-sectional sample of UK university students. Setting:
Emily K Round +3 more
doaj +1 more source
Evidence on the Efficacy of School-Based Incentives for Healthy Living [PDF]
We analyze the effects of a school-based incentive program on children's exercise habits. The program offers children an opportunity to win prizes if they walk or bike to school during prize periods.
Giancarlo Musto +4 more
core
The local evaluation of Halton's Healthy Living Programme annual reach report, August 2005 - July 2006 [PDF]
, 2006 This project report evaluates the Halton Healthy Living Programme, of which there are four key strands - arts, complementary therapy, food and physical ...
Alford, Simon, Perry, Catherine
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Triangulating nutrigenomics, metabolomics and microbiomics toward personalized nutrition and healthy living. [PDF]
Hum Genomics, 2023 Lagoumintzis G, Patrinos GP.
europepmc +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source