Results 251 to 260 of about 1,887,079 (308)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga   +2 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Healthy lifestyles, healthy lives

A Life in the Day, 2005
People with long‐term, severe mental health problems are at higher risk of premature death linked to lifestyle. They are more likely to smoke, to be overweight, and to take little or no exercise. Their physical health needs also tend notoriously to be neglected by the health services.
Diane Crone   +5 more
openaire   +1 more source

Healthy Portions, Healthy Living

2010
The effect portion sizes have had on the obesity epidemic, and how the Volumetrics Diet might be a way to downsize.
Benarba, Farah   +3 more
openaire   +1 more source

Healthy Living

2020
Abstract This chapter in the Oxford Handbook of General Practice explores how to give healthy living advice to patients. It looks at prevention and screening, including prevention of travel-related illness. It discusses the effect of diet, obesity, exercise, smoking, insomnia, and alcohol on general health, as well as the management of ...
Chantal Simon   +5 more
openaire   +2 more sources

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