Results 161 to 170 of about 149,447 (299)

Cost‐utility analysis of nusinersen–risdiplam switch in patients with spinal muscular atrophy in Croatia: A discrete event simulation model

British Journal of Clinical Pharmacology, EarlyView.
Introduction In recent years, the treatment of spinal muscular atrophy (SMA), a rare disease, has significantly progressed, improving patients' survival and overall quality of life. However, current SMA treatments are expensive, and some (nusinersen) are very inconvenient for patients.
Andrej Belančić, Ivana Stević, Elvira Meni Maria Gkrinia, Dinko Vitezić, Slobodan Janković   +4 more
wiley   +1 more source

Factors, Motivating People with Hearing Disorders to Physical Exercises and Sports

, 2012
The article adduces the results of the research aimed at boosting motivation of individuals with hearing disorders to physical exercises and sports.
Makhov, Alexandr
core  

Prevalence of Hearing Disorders among Type 2 Diabetes Mellitus Patients with and without Vitamin D Deficiency. [PDF]

Maedica (Bucur), 2020
Hosseini MS, Saeedi M, KHALKHALi SA.
europepmc   +1 more source

Adverse events in bedaquiline‐ and pretomanid‐based regimens for drug‐resistant tuberculosis from trial, implementation and pharmacovigilance studies

British Journal of Clinical Pharmacology, EarlyView.
Abstract The availability of safety data, particularly concerning adverse events (AEs) associated with the new shorter regimen for drug‐resistant tuberculosis (TB) containing a bedaquiline–pretomanid‐based regimen, is still limited. This systematic review aims to provide a comprehensive and updated analysis of AEs related to this new regimen by ...
Nisa Maria, Annisa Lazuardi Larasati, Indri Yuliani Hamdani, Jin‐Gun Cho, Jan‐Willem C. Alffenaar   +4 more
wiley   +1 more source

[Future cure of hearing disorders? Gene therapy and stem cell implantation are possible new therapeutic alternatives]

, 2000
Hearing loss is a very common disorder; nearly 10 per cent of the population is affected. Recently, a few findings such as the roles of neurotrophins, nitric oxide, reactive oxygen species and glutamate receptors in the peripheral hearing system have ...
Duan, ML, Pyykkö, I, Ahlberg, A, Borg, E, Ulfendahl, M,   +4 more
core  

Optimizing non-invasive functional markers for cochlear deafferentation based on electrocochleography and auditory brainstem responses. [PDF]

J Acoust Soc Am, 2022
Harris KC, Bao J.
europepmc   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Artificial Intelligence and Machine Learning in Audiology and Hearing Disorders: A Scoping Review with Bibliometric and Thematic Mapping (1995-2025). [PDF]

Audiol Res
Aksoy Koçak C.
europepmc   +1 more source

Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis

British Journal of Clinical Pharmacology, EarlyView.
Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood, Sarah Bannister, Stephen Duffull, April Martinez, Sarath Ranganathan, Shivanthan Shanthikumar, Amanda Gwee   +6 more
wiley   +1 more source

Influence of metabolic syndrome in the occurrence of hearing disorders in the Democratic Republic of Congo

Background: The assessment of hearing function in human life is important, because good hearing is important for social participation and inclusion in employment and education.
Benjamin Longo-Mbenza, Aliocha Natuhoyila Nkodila, Jérôme Gedikondele Sokolo, Richard Nzanza Matanda, Gabriel Mabwaka Lema, Pius Zakayi Kabututu   +5 more
core   +1 more source