Results 101 to 110 of about 3,864,619 (301)

Heart-lung machine, 1959

, 1959
Marjorie St. John assembling the newly arrived heart-lung machine at Yale-New Haven Medical Centerhttps://elischolar.library.yale.edu/ynhh_photos/1816/thumbnail ...
Sunday Magazine
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Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Early lymphocyte levels and low doses radiation exposure of lung predict lymphopenia in radiotherapy for lung cancer

Frontiers in Immunology
IntroductionRadiation induced lymphopenia (RIL) deteriorate survival and diminishes the benefit of immune checkpoint inhibitors in combined treatment of lung cancer.
Łukasz Kuncman, Łukasz Kuncman, Matusz Pajdziński, Matusz Pajdziński, Krzysztof Smółka, Mateusz Bilski, Mateusz Bilski, Mateusz Bilski, Joanna Socha, Rafał Stando, Magdalena Peszyńska-Piorun, Katarzyna Korab, Barbara Alicja Jereczek-Fossa, Barbara Alicja Jereczek-Fossa, Jacek Fijuth, Jacek Fijuth   +15 more
doaj   +1 more source

The role of Hedgehog acyltransferase in Sonic hedgehog signalling [PDF]

, 2012
Protein acyltransferases (PATs), a group of enzymes catalysing fatty acylation of a variety of proteins, play an important role in protein sorting and signalling in the cell. In the Hedgehog (Hh) signalling pathway the PAT Hedgehog acyltransferase (Hhat)
Jovanovic, Biljana
core   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Heart-Lung Machine

, 1957
North Carolina Baptist Hospital Nurses (L-R) Anne Casstevens and Marian Huffman and Dr. Charles E. Whitcher, anesthesiologist, inspect the heart-lung machine.
Wilson, Woodrow
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Nanomechanics of cell membrane and cellular contacts in control and failing hearts [PDF]

, 2019
In recent years, a growing number of studies have shown that mechanical properties play an important role in both structure and function of cells. Heart is an extremely dynamic organ; therefore, cardiac myocytes are constantly subjected to a mechanical ...
Swiatlowska, Pamela
core   +1 more source

scTIDE: Deciphering Critical Transitions Through Cell‐Perturbed Manifold Graphs and Optimal Transport Conditional Flow Matching

Advanced Science, EarlyView.
scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong, Bowen Niu, Yongbo Yu, Shiyang Nie, Xuerong Gu, Pei Chen, Rui Liu   +6 more
wiley   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Heart-Lung Bypass Machine

This is a 1985 Stockert-Shiley Heart-Lung Bypass Machine donated by the former Southwest Florida Regional Medical Center. With this device, a professional Perfusionist maintained the patient\u27s circulation, lung function, temperature, and anesthesia ...
Museum of Medical History,
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