Results 111 to 120 of about 3,864,619 (301)

Associations between body mass index and lung function using Z-scores: a nonlinear relationship and machine learning classification modeling

Frontiers in Physiology
IntroductionThis study systematically investigated the relationship between body mass index (BMI) and lung function, incorporating Z-scores, thereby offering a novel approach to lung function management.MethodsData from the National Health and Nutrition ...
Wei Feng, Fei Lu, Jiangjiang Liu, Yu Zhang, Shiyu Shen, Haitao Ma   +5 more
doaj   +1 more source

Characteristics, Survival, and Outcomes of Lung and Heart-Lung Transplantation for Pulmonary Sarcoidosis in a Multicenter European Study Characteristics, Survival, and Outcomes of Lung and Heart-Lung Transplantation for Pulmonary Sarcoidosis in a Multicenter European Study

, 2020
PURPOSE: In the context of sarcoidosis, lung transplantation is often performed in patients with irreversible advanced lung disease unresponsive to medical therapy.
Reynaud-Gaubert, M., Gottlieb, J., Tissot, A., Knoop, C., Pavec, J. L., Schultz, H., Blanchard, E., Godinas, L., Leborgne, A., Harari, S., Bunel, V., Magnusson, Jesper,, Mornex, J., Gazengel, P., Fadel, E., Picard, C., Savale, L., Valeyre, D., Hirschi, S.   +18 more
core   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source

Fat free mass in patients with ischemic heart disease treated with corrective surgery without heart-lung machine

Medisan, 2016
A prospective and longitudinal study of 42 adults, of both sexes, with ischemic heart disease, treated with corrective surgery without heart-lung machine was carried out in the Territorial Center of Cardiovascular Surgery in Santiago de Cuba, aimed at ...
Raúl Ramón Rizo Rodríguez, Marcia Mesa Díaz, Ana Ibis Núñez Bourón, Ana Beatriz Pupo Leyte Vidal, Yergenia Matute Gaínza   +4 more
doaj  

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Healthy heart handbook for women

, 2003
Also available online, see World Wide Web.Mode of access: Internet.Mode of access: Internet from the National Heart, Lung, and Blood Institute web site.
National Heart, Lung, and Blood Institute., Sandmaier, Marian.   +1 more
core  

Gastric pacing for severe gastroparesis in a heart–lung transplant recipient

, 2004
Gastroparesis is a serious complication of lung and heart–lung transplantation that can lead to malnutrition, gastroesophageal reflux, aspiration pneumonia and deteriorating lung function.
Ziedalski, Tomasz, Shafazand, Shirin, Berry, Gerald J, Faul, John L, Yiannopoulos, Anna, Theodore, James, Robbins, Robert C   +6 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source