Results 141 to 150 of about 181,509 (297)

World's first en bloc heart-lung transplantation using the paragonix lungguard donor preservation system. [PDF]

J Cardiothorac Surg, 2023
Neto D, Guenthart B, Shudo Y, Currie ME.
europepmc   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Extended criteria donor organ use for heart-lung transplantation in the modern era. [PDF]

Clinics (Sao Paulo), 2023
Weingarten N, Iyengar A, Herbst DA, Helmers M, Meldrum D, Guevara-Plunkett S, Dominic J, Atluri P.   +7 more
europepmc   +1 more source

One‐step generation of heritable mitochondrial DNA multiplex‐engineered rats using DddA‐derived cytosine base editor

Animal Models and Experimental Medicine, EarlyView.
We established that mixed DdCBE microinjection is an efficient, heritable, and precise strategy for generating multiplex mtDNA mutant rats. This advancement significantly expands the utility of DdCBEs for mitochondrial disease modeling, providing a robust platform for exploring the pathogenic mechanisms of complex mtDNA mutations and developing ...
Xu Zhang, Keru Li, Lei Tan, Wei Chen, Shan Gao, Chenyang Liu, Shuo Pan, Jiayue He, Ning Liu, Gefan Wan, Wei Dong, Weining Kong, Bin Shen, Xiaolong Qi, Yuanwu Ma   +14 more
wiley   +1 more source

A gentler approach to monitor for heart transplant rejection

Frontiers in Cardiovascular Medicine
Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial ...
Jason F. Goldberg, Jason F. Goldberg, Aditya Mehta, Rupinder K. Bahniwal, Sean Agbor-Enoh, Palak Shah   +5 more
doaj   +1 more source

Sequential redo-bilateral lung transplantation in recipient with prior heart-lung transplantation with tracheal anastomosis. [PDF]

JTCVS Tech, 2023
Coster JN, Chan EG, Furukawa M, Pilewski JM, Nguyen MHT, Sanchez PG.   +5 more
europepmc   +1 more source

Quadruple-drug induction therapy in highly sensitized patients [PDF]

, 1988
Abendroth, D., Illner, Wolf-Dieter, Land, Walter, Schleibner, S.   +3 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Combined Heart-Lung Transplantation Outcomes in Asian Populations: National Database Analysis. [PDF]

JACC Asia, 2022
Shudo Y, Leipzig M, He H, Ingle SM, Bhatt RH, Shin HS, Woo YJ.   +6 more
europepmc   +1 more source

Stem cell–based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Animal Models and Experimental Medicine, EarlyView.
Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley   +1 more source