Results 11 to 20 of about 100,615 (218)

Heart-lung transplantation for idiopathic pulmonary arterial hypertension and giant pulmonary artery aneurysm – case report [PDF]

Journal of Cardiothoracic Surgery, 2020
Backgound Idiopathic pulmonary arterial hypertension (IPAH) is a rare condition that requires lung transplantation in patients’ refractory to medical therapy.
T. Eadington, K. Santhanakrishnan, R. Venkateswaran   +2 more
doaj   +2 more sources

Evolution of the Surgical Management of Lung Cancer Invading the Spine: A Single Center Experience

Current Oncology, 2022
For patients with locally advanced non-small cell lung cancer invading the spine, induction chemoradiotherapy combined with radical en bloc resection is the key to obtaining long-term survival.
Gabrielle Drevet, Théo Broussolle, Yanis Belaroussi, Lucie Duponchelle, Jean Michel Maury, Renaud Grima, Gualter Vaz, Clément Silvestre, François Tronc   +8 more
doaj   +1 more source

High-affinity CD16 integration into a CRISPR/Cas9-edited CD38 locus augments CD38-directed antitumor activity of primary human natural killer cells

Journal for ImmunoTherapy of Cancer, 2022
Background Adoptive transfer of natural killer (NK) cells with augmented antibody-dependent cellular cytotoxicity (ADCC) capabilities and resistance to CD38 targeting has the potential to enhance the clinical anti-myeloma activity of daratumumab (DARA ...
Long Chen, Richard Childs, Robert Reger, Mala Chakraborty, Joseph Andrew Clara, Emily R Levy, Stefan Barisic, Elena Cherkasova, David S J Allan   +8 more
doaj   +1 more source

Lung Transplantation for Pulmonary Arterial Hypertension: Optimized Referral and Listing Based on an Evolving Disease Concept

Journal of Cardiovascular Development and Disease, 2023
Pulmonary hypertension (PH) was once a devastating and fatal disease entity, the outlook of which has been significantly improved by the continued progress of medical treatment algorithms.
Xiaokun Hu, Ningying Ding, Wanqiu Songchen, Ruifeng Wang, Jing Chen, Ailing Zhong, Jinzhu Nan, Yujie Zuo, Heng Huang, Dong Tian   +9 more
doaj   +1 more source

Cardiac Imaging in Patients After Fontan Palliation: Which Test and When?

Frontiers in Pediatrics, 2022
The Fontan operation represents the final stage of a series of palliative surgical procedures for children born with complex congenital heart disease, where a “usual” biventricular physiology cannot be restored.
Paolo Ciliberti, Paolo Ciancarella, Pasqualina Bruno, Davide Curione, Veronica Bordonaro, Veronica Lisignoli, Mario Panebianco, Marcello Chinali, Aurelio Secinaro, Lorenzo Galletti, Paolo Guccione   +10 more
doaj   +1 more source

Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion

Molecular Therapy: Methods & Clinical Development, 2021
Transduction of primary human natural killer (NK) cells with lentiviral vectors has historically been challenging. We sought to evaluate multiple parameters to optimize lentiviral transduction of human peripheral blood NK cells being expanded to large ...
David S.J. Allan, Mala Chakraborty, Giacomo C. Waller, Michael J. Hochman, Akkapon Poolcharoen, Robert N. Reger, Richard W. Childs   +6 more
doaj   +1 more source

Medium term results following heart transplantation for end stage heart failure: A single center experience of 257 patients

Indian Heart Journal, 2020
Objective: End stage heart failure is a lethal disease with a dismal 5 year survival. Heart transplantation has proven to be a highly effective modality of treatment in appropriately selected group of such patients.
K.R. Balakrishnan, K.G. Sureshrao, R. Ravikumar, T. Muralikrishna, K. Ganapathy Subramaniam, R. Mohan, A. Ajay, K. Ramasubramanian, D. Jagdish, R. Veena   +9 more
doaj   +1 more source

Downregulation of Filamin a Expression in the Aorta Is Correlated With Aortic Dissection

Frontiers in Cardiovascular Medicine, 2021
Filamins (FLNs) are actin cross-linking proteins, and as scaffolding proteins, FLNs are closely associated with the stabilization of the cytoskeleton. Nevertheless, the biological importance of FLNs in aortic dissection (AD) has not been well-elucidated.
Yue Chen, Xiang Wei, Xiang Wei, Xiang Wei, Xiang Wei, Zihao Zhang, Yi He, Bo Huo, Xian Guo, Xin Feng, Ze-Min Fang, Ding-Sheng Jiang, Ding-Sheng Jiang, Ding-Sheng Jiang, Ding-Sheng Jiang, Xue-Hai Zhu, Xue-Hai Zhu, Xue-Hai Zhu, Xue-Hai Zhu   +18 more
doaj   +1 more source

Long-term outcomes after chest wall resection and repair with titanium bars and sternal plates

Frontiers in Surgery, 2022
ObjectivesEn-bloc complete resection remains the treatment of choice for localized chest wall (CW) tumors. Titanium bars reconstruction demonstrated encouraging results with satisfactory early outcomes.
Hugo Clermidy, Guillaume Fadel, Alexandra De Lemos, Pauline Pradere, Delphine Mitilian, Antoine Girault, Jean-Baptiste Menager, Dominique Fabre, Sacha Mussot, Nicolas Leymarie, Elie Fadel, Olaf Mercier   +11 more
doaj   +1 more source

Expanded NK cells used for adoptive cell therapy maintain diverse clonality and contain long-lived memory-like NK cell populations

Molecular Therapy: Oncolytics, 2023
Multiple clinical trials exploring the potential of adoptive natural killer (NK) cell therapy for cancer have employed ex vivo expansion using feeder cells to obtain large numbers of NK cells.
David S.J. Allan, Chuanfeng Wu, Ryland D. Mortlock, Mala Chakraborty, Katayoun Rezvani, Jan K. Davidson-Moncada, Cynthia E. Dunbar, Richard W. Childs   +7 more
doaj   +1 more source