Results 111 to 120 of about 132,211,819 (268)

Pressure‐Assisted Drug Delivery Using High‐Pressure Balloon Platform Improves Vascular Drug Penetration and Anti‐Restenotic Effects

Advanced Healthcare Materials, EarlyView.
A dual‐layer high‐pressure drug‐coated balloon (HP@DCB) increased balloon‐wall contact and promoted deeper paclitaxel (PTX) penetration than a conventional noncompliant DCB. In in vivo study, HP@DCB treatment improved luminal patency and reduced neointimal hyperplasia, supporting pressure‐assisted drug delivery as a promising strategy for enhancing the
Seung Jin Eo, So Yun Lim, Dong‐Sung Won, Ji Won Kim, Yubeen Park, Song Hee Kim, Hyemin Lee, Jung‐Min Ahn, Jun‐Kyu Park, Do‐Yoon Kang, Jung‐Hoon Park   +10 more
wiley   +1 more source

Modeling Early Metastatic Progression in Breast Cancer Using a Barrier‐Free, Perfusable Spheroid‐on‐a‐Chip Platform

Advanced Healthcare Materials, EarlyView.
Open‐port, barrier‐free microfluidic device for modeling early metastatic progression. A centrally positioned tumor spheroid releases invasive cells that migrate through the surrounding matrix and intravasate into endothelialized lateral channels.
Vira Sharko, Claudia Olaizola‐Rodrigo, Clara Bayona, Teodora Ranđelović, Rosa Monge, Estela Solanas, Sara Oliván, Ignacio Ochoa   +7 more
wiley   +1 more source

Moonrake chip - GALS demonstrator in 40 nm CMOS technology

, 2011
In this paper we present for the first time a complex GALS ASIC demonstrator in 40 nm CMOS process. This chip, named Moonrake, compares synchronous and GALS synchronization technology in a homogeneous experimental setting: same baseline designs, same ...
BERTOZZI, DAVIDE, KAKOEE, MOHAMMAD REZA, BENINI, LUCA, Sanders B., Krstic M., Strano A., Grass E., Heer C., Fan X.   +8 more
core   +1 more source

Biological aging and incident cardiovascular diseases in individuals with diabetes: insights from a large prospective cohort study

Cardiovascular Diabetology
Background Biological aging is a critical risk factor of age-related diseases, but its impact on diabetic individuals remains unclear. This study aimed to examine the associations of biological aging with the incident cardiovascular diseases (CVDs) and ...
Zhiwei Zeng, Chunyu Yu, Runze Chen, Zhongchen Li, Peng Wang, Xueying Wang, Xi Li, Zhe Zheng   +7 more
doaj   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?

Frontiers in Cell and Developmental Biology, 2023
Irene Bissoli, Stefania D’Adamo, Carla Pignatti, Giulio Agnetti, Giulio Agnetti, Giulio Agnetti, Flavio Flamigni, Flavio Flamigni, Silvia Cetrullo, Silvia Cetrullo   +9 more
doaj   +1 more source

Human cardiac innervation-on-a-chip platform recapitulates neurocardiac interactions and supports future disease modeling

Scientific Reports
The cardiac autonomic nervous system regulates cardiac function through innervation, and dysfunction of the neuronal and cardiovascular crosstalk has been linked to various pathologies.
Emma Pesu, Elias Kuusela, Anna-Mari Moilanen, Andrey Vinogradov, Kaisa Tornberg, Henna Lappi, Lassi Sukki, Tomi Ryynänen, Timo Salpavaara, Fikret Emre Kapucu, Pasi Kallio, Katriina Aalto-Setälä, Susanna Narkilahti   +12 more
doaj   +1 more source

Electrical stimulation: a missing key to promote maturation of human pluripotent stem cell-derived cardiomyocytes in three-dimensional cardiac tissues

Frontiers in Bioengineering and Biotechnology
The maturation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) remains a major challenge in developing functional in vitro cardiac models.
Sem Sterckel, Robert Passier, Robert Passier, José Manuel Rivera-Arbelaez, José Manuel Rivera-Arbelaez   +4 more
doaj   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Lab on a chip for continuous-flow magnetic cell separation

, 2015
Separation of cells is a key application area of lab-on-a-chip (LOC) devices. Among the various methods, magnetic separation of cells utilizing microfluidic devices offers the merits of biocompatibility, efficiency, and simplicity.
Hejazian, Majid, Weihua Li, Li, Weihua, Nam-Trung Nguyen, Nam-Trung, Nguyen, Majid Hejazian   +5 more
core   +1 more source