Results 141 to 150 of about 132,211,819 (268)

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation. [PDF]

Biomaterials, 2023
Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Massé S, Cox BJ, Lai P, Liang T, Landau S, Protze S, Gao XD, Wang EY, Tung KC, Laksman Z, Lu RXZ, Keller G, Nanthakumar K, Radisic M, Backx PH.   +19 more
europepmc   +1 more source

Vitamin C‐Induced Photo‐Redox Threshold Enables High‐Fidelity Volumetric Printing of Collagen

Advanced Materials, EarlyView.
Tomographic volumetric printing (TVP) of native proteins is limited by uncontrolled background crosslinking. Here, vitamin C is introduced as a biocompatible redox regulator to establish a tunable nonlinear polymerization threshold response for TVP.
Bin Wang, Amelia Hasenauer, Kristian Ivkovic, Ann‐Sophie Frind, David Fercher, Marcy Zenobi‐Wong   +5 more
wiley   +1 more source

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

, 2018
ABSTRACT Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) are a promising in vitro tool for drug development and disease modeling, but their immature electrophysiology limits their diagnostic utility. Tissue engineering approaches involving aligned and 3D culture enhance hiPSC-CM maturation but are insufficient to induce ...
Huebsch, Nathaniel, Charrez, Berenice, Siemons, Brian, Boggess, Steven C., Wall, Samuel, Charwat, Verena, Jæger, Karoline H., Lee Montiel, Felipe T., Jeffreys, Nicholas C., Deveshwar, Nikhil, Edwards, Andrew, Serrano, Jonathan, Snuderl, Matija, Stahl, Andreas, Tveito, Aslak, Miller, Evan W., Healy, Kevin E.   +16 more
openaire   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

A Bioprinted Heart-on-a-Chip with Human Pluripotent Stem Cell-Derived Cardiomyocytes for Drug Evaluation. [PDF]

Bioengineering (Basel), 2022
Faulkner-Jones A, Zamora V, Hortigon-Vinagre MP, Wang W, Ardron M, Smith GL, Shu W.   +6 more
europepmc   +1 more source

Characterized Ecoflex Polydimethylsiloxane (PDMS) Hybrids for Advanced Flexible Devices

Advanced Materials Technologies, EarlyView.
Ecoflex–PDMS hybrids are systematically characterized to identify an optimal composition that balances stretchability, optical transparency, and plasma bonding, enabling multifunctional applications in stretchable microfluidics, flexible sensing, and soft robotics.
Xiaoyue Kang, Zhefan Chen, Zhiyang Hong, Wanting Chen, Qingtian Zhang, Amith Mudugamuwa, Tuan‐Khoa Nguyen, Lingxi Ouyang, Nam‐Trung Nguyen, Jun Zhang, Dan Yuan   +10 more
wiley   +1 more source

Lab on a chip: a key platform for biomedicine application

, 2008
Lab on a Chip (called ""Microfluidics"") has established itself as an important technology in the area of system biology...
林炳承
core  

The hanging‐heart chip: A portable microfluidic device for high‐throughput generation of contractile embryonic stem cell‐derived cardiac spheroids

Bioengineering & Translational Medicine
Stem cell‐derived cardiac spheroids are promising models for cardiac research and drug testing. However, generating contracting cardiac spheroids remains challenging because of the laborious experimental procedure. Here, we present a microfluidic hanging‐
Pei‐Tzu Lai, Cheng‐Kun He, Chi‐Han Li, Jefunnie Matahum, Chia‐Yu Tang, Chia‐Hsien Hsu   +5 more
doaj   +1 more source

Automated culture and monitoring of a high-throughput human heart-on-a-chip

Abstract Organ chips offer a disruptive innovation to study human diseases with tissue-specific resolution within a predictable and tunable in vitro environment. However, these platform technologies have for the most part failed to translate to broad use in the private sector due to a lack of high-throughput, user-friendly platforms ...
Bryan G. Schellberg, Nolan T. Burson, Joshua Gomes, Guohao Dai, Abigail N. Koppes, Ryan A. Koppes   +5 more
openaire   +1 more source