Results 121 to 130 of about 82,439 (260)

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation

, 2019
Background Skeletal muscle myopathy and exercise intolerance are diagnostic hallmarks of heart failure (HF). However, the molecular adaptations of skeletal muscles during dilated cardiomyopathy (DCM)-mediated HF are not completely understood.
Jack Rubinstein, Palanikumar Manoharan, Douglas P. Millay, Judith A. Heiny, Sheryl E. Koch, Taejeong Song, Sakthivel Sadayappan   +6 more
core   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

Mecanismes fisiopatològics de la miocardiopatia alcohòlica: canals de calci, apoptosi i estrés oxidatiu. [PDF]

, 2006
[cat] INTRODUCCIÓ:La miocardiopatia alcohòlica (MCPA) és una malaltia específica del muscle cardíac de causa coneguda i que està classificada dins dels grup de les cardiomiopaties dilatades, tot i que en ocasions es fa referència a aquesta entitat com a
Fatjó i Hurios, Francesc
core  

Skeletal muscle abnormalities in heart failure with preserved ejection fraction

, 2023
INTRODUCTION: Heart failure with preserved ejection fraction (HFpEF) accounts for half of all clinical heart failure presentations, but unfortunately lacks effective therapies.
Werner, Louis
core  

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Cardiac Cachexia: Perspectives for Prevention and Treatment

Arquivos Brasileiros de Cardiologia
Cachexia is a prevalent pathological condition associated with chronic heart failure. Its occurrence predicts increased morbidity and mortality independent of important clinical variables such as age, ventricular function, or heart failure functional ...
Marina Politi Okoshi, Rafael Verardino Capalbo, Fernando G Romeiro, Katashi Okoshi   +3 more
doaj   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Effects of pentoxifylline on exercising skeletal muscle vascular control in rats with chronic heart failure

Master of ScienceDepartment of KinesiologyTimothy I. MuschBoth cardiac and peripheral vasculature dysfunction likely contribute, in part, to elevations in TNF-[alpha] and exercise intolerance in chronic heart failure (CHF). The pharmaceutical TNF-[alpha]
Rico, Gabrielle
core  

Dual‐Network Protein Hydrogels Promote Rapid Hemostasis and Immune‐Regulated Scarless Tissue Regeneration

Advanced Science, EarlyView.
A dual‐network protein hydrogel substantially improves hemostasis and scar‐free healing.The adaptive network maintains intimate tissue contact while providing strong wet adhesion, tunable mechanics, and controlled degradation. Concurrent ROS scavenging and M2 polarization suppress fibrotic pathways, preventing scar formation.
Xiaomei Li, Guorui Zhang, Xinyue Wang, Zhongyu Liu, Ling Yang, Yuhan Bao, Min Wei, Yonglin Chen, Yanfei Ma, Wenbo Sheng, Bo Yu, Bin Li   +11 more
wiley   +1 more source

Evolution of the Piscine orthoreovirus Genome Linked to Emergence of Heart and Skeletal Muscle Inflammation in Farmed Atlantic Salmon (Salmo salar). [PDF]

Viruses, 2019
Dhamotharan K, Tengs T, Wessel Ø, Braaen S, Nyman IB, Hansen EF, Christiansen DH, Dahle MK, Rimstad E, Markussen T.   +9 more
europepmc   +1 more source