Results 141 to 150 of about 158,304 (253)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Correction: The rise of rat models for Duchenne muscular dystrophy and therapeutic evaluations. [PDF]

Skelet Muscle
Relaix F, Lafuste P, Taglietti V, Tiret L.   +3 more
europepmc   +1 more source

Diabetes adversely affects phospholipid profiles in human carotid artery endarterectomy plaques [PDF]

, 2018
Darwesh, Malik, De Silva, Gayan, Hsu, Fong-Fu, Naim, Uzma, Patterson, Bruce W., Semenkovich, Clay F., Yan, Yan, Yang, Chao, Zayed, Mohamed A.   +8 more
core   +2 more sources

Astrocytic Mitochondria Transplantation Rescues Neuron Loss and Dendritic Injuries in Acute Cerebral Ischemic Stroke Mouse Model by Flexibly Regulating Mitochondria Dynamics

Annals of Neurology, EarlyView.
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei   +9 more
wiley   +1 more source

Potential plasma biomarkers for the onset of heart and skeletal muscle inflammation from Piscine orthoreovirus-1 infection in Atlantic salmon (Salmo salar)

Aquaculture, 2023
Christiane Kruse Fæste, Oscar Daniel Rangel Huerta, Jan Haug Anonsen, Haitham Tator, Raoul Valentin Kuiper, Maria Krudtaa Dahle   +5 more
openaire   +1 more source

Estimation and rapid identification of later stages during embryonic development of the oviparous lizard Sceloporus aeneus (Squamata: Phrynosomatidae)

The Anatomical Record, EarlyView.
Abstract Stages of embryonic development for reptiles have been presented in tables that may include all or part of embryonic development. When oviposition occurs in some lizards, embryos are already in the later stages of development; likewise, the size of the eggs increases as incubation time progresses.
Nivia Rocio Antonio‐Rubio, Maricela Villagrán‐SantaCruz, Martha Elena Díaz‐Hernández, Norma Moreno‐Mendoza   +3 more
wiley   +1 more source

Acute myocarditis and rhabdomyositis after coronavirus disease 2019 messenger RNA vaccination and intensive training: a case report. [PDF]

J Med Case Rep
Wu J, Szakos A, Bozoky B, Szekely L.
europepmc   +1 more source

A contribution to the anatomy of two rare cetacean species: The hourglass dolphin (Cephalorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica)

The Anatomical Record, EarlyView.
Abstract The anatomical description of the hourglass dolphin (Cephalorhynchus cruciger) and the spectacled porpoise (Phocoena dioptrica) remains largely unexplored, due to limited specimen availability and preservation challenges. This study employed digital imaging techniques, conventional histology, and computed tomography to provide visualization of
Jean‐Marie Graïc, Tommaso Gerussi, Bruno Cozzi, Rebecca M. Boys, Brian Chin Wing Kot, Matthew R. Perrott, Kane Fleury, Tabris Yik To Chung, Henry Chun Lok Tsui, Emma Burns, Trudi Webster, Stuart Hunter, Emma L. Betty, Odette Howarth, Carolina Loch, Sophie White, Steve Dawson, William Rayment, Ros Cole, Derek Cox, Tom Waterhouse, Hannah Hendriks, Anton van Helden, Muriel Johnstone, Ramari Oliphant Stewart, R. Ewan Fordyce, Karen A. Stockin   +26 more
wiley   +1 more source

The Conjugated Bile Acids Profile Suggests a Novel Liver-Muscle Axis Associated With Sarcopenia in Chronic Liver Disease. [PDF]

Liver Int
Iwasa M, Eguchi A, Kohjima M, Miyazaki T, Kitamura H, Takami Y, Yamashita N, Tempaku M, Izuoka K, Kobayashi Y, Takei Y, Honda A, Nakagawa H, Ikegami T, Nakamuta M, Okabe J, Montano-Loza AJ.   +16 more
europepmc   +1 more source

The tiger salamander as a promising alternative model organism to the axolotl for fracture healing and regenerative biology research

The Anatomical Record, EarlyView.
Abstract Scientists have been captivated by the ability to regenerate, focusing on uncovering the mechanisms of epimorphic regeneration and applying them to human medicine. The axolotl (Ambystoma mexicanum) has become the most intensively studied model in tetrapod regeneration research, particularly concerning limb regeneration.
Vivien Bothe, Nadia Fröbisch
wiley   +1 more source