Results 231 to 240 of about 159,878 (309)

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

The Potential Role of Iron Homeostasis and Ferroptosis in Exercise Nutrition and Health. [PDF]

Nutrients
Wang Q, Gao R, Zhu K, Qiu H, Huang J, Zhang X.   +5 more
europepmc   +1 more source

Plant‐derived extracellular vesicle‐like particles as novel osteoanabolic agents: Activating bone morphogenetic protein 2/Smads signaling axis for bone regeneration in postmenopausal osteoporosis

Interdisciplinary Medicine, EarlyView.
Illustration depicting the isolation of Dipsaci Radix derived extracellular vesicle‐like particles and their function in alleviating osteoporosis. (A) Extraction and characterization detection process of extracellular vesicle‐like particles derived from Dipsaci Radix roots. (B) Cell experiments in vitro, Dipsaci Radix derived extracellular vesicle‐like
Qing Zhao, Yue Cao, Zhengting Wu, Yingqi Cao, Qi You, Yuanyuan Xia, Xuejun Tan, Dongxiao Li, Tianxin Qiu, Xiuping Cai, Zhaodi Guo, Lei Zheng, Kewei Zhao   +12 more
wiley   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling. [PDF]

J Cachexia Sarcopenia Muscle
Przymuszała M, Białobrzeska M, Dulak J, Florczyk-Soluch U.   +3 more
europepmc   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

Interdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang   +12 more
wiley   +1 more source

Targeting cellular senescence in dystrophin^-/-/utrophin^-/-double knockout mice improves musculoskeletal health and increases lifespan. [PDF]

Pharmacol Res
Gao X, Ruzbarsky JJ, Huard M, Sajedi SAH, Shyu PT, Xiao Z, Force BS, White S, Ayers J, Wang B, Guo XE, Huard J.   +11 more
europepmc   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Diabetes and its complications: molecular mechanisms, prevention and treatment. [PDF]

Signal Transduct Target Ther
Zhao L, Yuan J, Yang Q, Ma J, Yang F, Zou Y, Liu K, Liu F.   +7 more
europepmc   +1 more source

Prevalence and Mechanisms of Sustained Force Production in the Musculature of the Southern Alligator Lizard (Elgaria multicarinata)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The southern alligator lizard (Elgaria multicarinata) exhibits prolonged mate‐holding behavior. This behavior maybe be underpinned by a phenomenon known as sustained force, observed in the jaw muscles of this species, in which the muscle fails to relax between subsequent contractions.
Allyn Nguyen, Kyle Leong, Jessica Phan, Natalie Holt   +3 more
wiley   +1 more source

Recovery of Physical Function during Hospitalization among Heart Failure Patients with and without Cachexia. [PDF]

Phys Ther Res
Umehara T, Kaneguchi A, Nakashima Y, Yamamoto Y, Katayama N, Kito N.   +5 more
europepmc   +1 more source