Results 31 to 40 of about 181,250 (261)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
, 2017 Background: Adequate cerebral blood flow maintained by optimal blood pressure is important in neurological recovery for patients sustaining transient brain ischemia.
Wang, Chih-Hung;Huang, Chien-Hua;Chang, Wei-Tien;Tsai, Min-Shan;Yu, Ping-Hsun;Wang, An-Yi;Chen, Nai-Chuan;Chen, Wen-Jone +1 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
, 2017 In addition to cardiac output, oxygen delivery is determined by the amount of oxygen carried by hemoglobin, which is estimated by the product of hemoglobin level and peripheral hemoglobin oxygen saturation (SpO(2)).
Wang, Chih-Hung;Huang, Chien-Hua;Chang, Wei-Tien;Tsai, Min-Shan;Yu, Ping-Hsun;Wang, An-Yi;Chen, Nai-Chuan;Chen, Wen-Jone +1 more
core +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
, 2017 Aim: Resuscitation guidelines indicate the ideal timing of tracheal intubation during in-hospital cardiac arrest (IHCA) has not been adequately studied. ;Methods: A retrospective observational study in a single medical centre was conducted that evaluated
Wang, Chih-Hung;Chen, Wen-Jone;Chang, Wei-Tien;Tsai, Min-Shan;Yu, Ping-Hsun;Wu, Yen-Wen;Huang, Chien-Hua +1 more
core +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Regenerating Hearts by Arresting Development With Hypothyroidism [PDF]
Circulation Research, 2019 A recent report by Hirose et al highlights the divergence in cardiac regenerative potential across phylogeny and mouse ontogeny. They provide a correlation between metabolic rate and cardiomyocyte ploidy across species, linking whole-body metabolic control to endothermics and to thyroid function.
Sean, Lal, Bernhard, Kühn
openaire +2 more sources