Results 41 to 50 of about 1,742,602 (286)

Heart rate as a marker of relapse during withdrawal of therapy in recovered dilated cardiomyopathy [PDF]

, 2021
Objectives: The objective of this study was to determine the relationship between heart rate and relapse among patients in the TRED-HF (Therapy withdrawal in REcovered Dilated cardiomyopathy trial). Background: Understanding markers and mechanisms
Owen, Ruth, Prasad, Sanjay K, Khalique, Zohya, Prasad, Sanjay K., Pantazis, Antonis, Lota, Amrit, Vazir, Ali, Hammersley, Daniel, Cleland, John, Pennell, Dudley J., Wassall, Rebecca, Halliday, Brian, Baksi, Arun, Halliday, Brian P, Lota, Amrit S., Baksi, A. John, Jones, Richard, Cowie, Martin R, Gregson, John, Prasad, Sanjay, Baksi, A John, Pennell, Dudley J, Cleland, John GF, Tayal, Upasana, Rosen, Stuart, Cleland, John G.F., Cowie, Martin R., Jones, Richard E., Lota, Amrit S, Jones, Richard E, Cowie, Martin, Pennell, Dudley, Halliday, Brian P.   +32 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Enhanced Activity by NKCC1 and Slc26a6 Mediates Acidic pH and Cl− Movement after Cardioplegia-Induced Arrest of db/db Diabetic Heart

Mediators of Inflammation, 2019
Diabetic heart dysfunctions during cardiac surgeries have revealed several clinical problems associated with ion imbalance. However, the mechanism of ion imbalance mediated by cardioplegia and a diabetic heart is largely unclear. We hypothesized that ion
Minjeong Ji, Seok In Lee, Sang Ah Lee, Kuk Hui Son, Jeong Hee Hong   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Sex-specific health-related quality of life in survivors of cardiac arrest

Resuscitation Plus
Survival after out-of-hospital cardiac arrest (OHCA) remains low, although the number of survivors is increasing, and survivors are living longer. With increasing long-term survival, there is a need to understand health-related quality of life (HRQoL ...
Kaitlyn Ghassemi, Kyndaron Reinier, Sumeet S. Chugh, Faye L. Norby   +3 more
doaj   +1 more source

Regions With Low Rates of Bystander Cardiopulmonary Resuscitation (CPR) Have Lower Rates of CPR Training in Victoria, Australia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundBystander cardiopulmonary resuscitation (CPR) more than doubles the chance of surviving an out‐of‐hospital cardiac arrest. Recent data have shown considerable regional variation in bystander CPR rates across the Australian state of Victoria ...
Janet E. Bray, Lahn Straney, Karen Smith, Susie Cartledge, Rosalind Case, Stephen Bernard, Judith Finn   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Hypothermia and postconditioning after cardiopulmonary resuscitation reduce cardiac dysfunction by modulating inflammation, apoptosis and remodeling [PDF]

, 2009
Background: Mild therapeutic hypothermia following cardiac arrest is neuroprotective, but its effect on myocardial dysfunction that is a critical issue following resuscitation is not clear.
Meybohm, Patrick, Zitta, Karina, Matthias Gruenewald, Nguyen Tran, Grünewald, Matthias Lars, Martin Albrecht, Koch, Alexander, Karina Zitta, Lucius, Ralph, Scholz, Jens, Kai D Zacharowski, Patrick Meybohm, Bein, Berthold Helmut, Berthold Bein, Albrecht, Martin, Ralph Lucius, Jens Scholz, Alexander Koch, Zacharowski, Kai, Tran, Thi Hoai Nguyen   +19 more
core   +2 more sources

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source