Results 41 to 50 of about 160,317 (273)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Predictors of cardio pulmonary resuscitation outcome in postoperative cardiac children

Journal of the Saudi Heart Association, 2016
Background: Outcomes of cardiopulmonary resuscitation (CPR) in children with congenital heart disease have improved and many children have survived after an in-hospital cardiac arrest.
Bana Agha Nasser, Julinar Idris, Abdu Rahman Mesned, Tageldein Mohamad, Mohamed S. Kabbani, Ali Alakfash   +5 more
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

A comprehensive neuromonitoring approach in a large animal model of cardiac arrest

Animal Models and Experimental Medicine, 2022
Background Anoxic brain injuries represent the main determinant of poor outcome after cardiac arrest (CA). Large animal models have been described to investigate new treatments during CA and post‐resuscitation phase, but a detailed model that includes ...
Filippo Annoni, Lorenzo Peluso, Lucas Akira Hirai, Giovanni Babini, Amina Khaldi, Antoine Herpain, Lorenzo Pitisci, Lorenzo Ferlini, Bruno Garcia, Fabio Silvio Taccone, Jacques Creteur, Fuhong Su   +11 more
doaj   +1 more source

On the Validity of Arrest as a Proxy for Offense: Race and the Likelihood of Arrest for Violent Crimes [PDF]

arXiv, 2021
The risk of re-offense is considered in decision-making at many stages of the criminal justice system, from pre-trial, to sentencing, to parole. To aid decision makers in their assessments, institutions increasingly rely on algorithmic risk assessment instruments (RAIs).
arxiv  

Secure and Robust Machine Learning for Healthcare: A Survey [PDF]

arXiv, 2020
Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional medical images.
arxiv  

Electroencephalography as a tool to predict cerebral oxygen metabolism during deep-hypothermic circulatory arrest in neonates with critical congenital heart diseaseCentral MessagePerspective

JTCVS Open, 2023
Objectives: Recent research suggests that increased cerebral oxygen use during surgical intervention for neonates with congenital heart disease may play a role in the development of postoperative white matter injury.
Gerard H. Laurent, ScB, Tiffany S. Ko, PhD, Kobina G. Mensah-Brown, MD, MS, Constantine D. Mavroudis, MD, MSC, MTR, Marin Jacobwitz, CRNP, PhD, Nicolina Ranieri, BSc, Susan C. Nicolson, MD, J. William Gaynor, MD, Wesley B. Baker, PhD, Daniel J. Licht, MD, Shavonne L. Massey, MD, MSCE, Jennifer M. Lynch, MD, PhD   +11 more
doaj  

Turbulent cascade arrests and the formation of intermediate-scale condensates [PDF]

Energy cascades lie at the heart of the dynamics of turbulent flows. In a recent study of turbulence in fluids with odd-viscosity [de Wit \textit{et al.}, Nature \textbf{627}, 515 (2024)], the two-dimensionalization of the flow at small scales leads to the arrest of the energy cascade and selection of an intermediate scale, between the forcing and the ...
arxiv   +1 more source

A New Theory of Dynamic Arrest in Colloidal Mixtures [PDF]

, 2007
We present a new first-principles theory of dynamic arrest in colloidal mixtures based on the multi-component self-consistent generalized Langevin equation (SCGLE) theory of colloid dynamics [Phys. Rev. E {\bf 72}, 031107 (2005); ibid {\bf 76}, 039902 (2007)].
arxiv   +1 more source