Results 71 to 80 of about 375,872 (318)

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

open access: yesFEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang   +7 more
wiley   +1 more source

Complete heart block? [PDF]

open access: yesEuropace, 2011
This patient was admitted 3-months post-orthotopic heart transplantation (biatrial anastomosis) with the following electrocardiogram (ECG). The anastomosis resulted in electrical …
Hoong Sern Lim   +4 more
openaire   +3 more sources

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

open access: yesFEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma   +3 more
wiley   +1 more source

Postural heart block. [PDF]

open access: yesHeart, 1980
A patient presented with orthostatic dizziness and syncope caused by postural heart block. When the patient was supine, atrioventricular conduction was normal and he was asymptomatic; when he was standing he developed second degree type II block and symptoms.
P E Seda, J H McAnulty, C J Anderson
openaire   +3 more sources

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

open access: yesFEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli   +15 more
wiley   +1 more source

Sex based disparities in hospitalization and readmission outcomes for complete atrioventricular block: Insights from United States readmission data

open access: yesJournal of Arrhythmia
Background Sex disparities in cardiovascular disorders are well‐documented, but data on hospitalization and readmission outcomes in the context of sex for Complete Heart Block (CHB) remains limited.
Nadhem Abdallah   +2 more
doaj   +1 more source

Bloqueio cardíaco completo em espondilite anquilosante Complete heart block in ankylosing spondylitis

open access: yesRevista Brasileira de Reumatologia, 2012
A espondilite anquilosante é uma doença reumática crônica de homens jovens que afeta principalmente o esqueleto axial e está associada ao HLA-B27 em 90% dos casos.
Juan Pablo Restrepo   +1 more
doaj   +1 more source

Higher order spectral analysis of ECG signals [PDF]

open access: yesarXiv, 2018
Higher Order Spectral (HOS) analysis is often applied effectively to analyze many bio-medical signals to detect nonlinear and non-Gaussian processes. One of the most basic HOS methods is the bispectral estimation, which extracts the degree of quadratic phase coupling between individual frequency components of a nonlinear signal.
arxiv  

The effect of multi‐leaf collimator leaf width on VMAT treatment plan quality

open access: yesJournal of Applied Clinical Medical Physics, EarlyView.
Abstract Background The advent of volumetric modulated arc therapy (VMAT) in radiotherapy has made it one of the most commonly used techniques in clinical practice. VMAT is the delivery of intensity modulated radiation therapy (IMRT) while the gantry is in motion, and existing literature has shown it has decreased treatment delivery times and the ...
Gregory Sadharanu Peiris   +3 more
wiley   +1 more source

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