Results 61 to 70 of about 59,843 (260)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Limitations of adjustment for reporting tendency in observational studies of stress and self reported coronary heart disease [PDF]

, 2002
Recently, observational evidence has been suggested to show a causal association between various "psychosocial" exposures, including psychological stress, and heart disease. Much of this evidence derives from studies in which a self reported psychosocial
Macleod, J, Hart, C., Macleod, John, Heslop, P., Metcalfe, C, Hart, C, Heslop, P, Metcalfe, CR, Davey Smith, G., Carroll, Douglas, Davey Smith, G, Metcalfe, C., Carroll, D., Macleod, J., J Macleod, Carroll, D   +15 more
core   +1 more source

Gender-specific risk factors for heart disease in middle-aged people

Медицинский совет, 2013
A complex clinical, laboratory and instrumental examination of 234 patients found that hypertension occurs with equal frequency in men and women.
R. I. Stryuk, Y. V. Brytkova, B. N. Burlakova, T. I. Romashkina   +3 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Sex differences in risk factors for cardiovascular disease: the PERU MIGRANT study. [PDF]

, 2012
INTRODUCTION: Although men and women have similar risk factors for cardiovascular disease, many social behaviors in developing countries differ by sex. Rural-to-urban migrants have different cardiovascular risk profiles than rural or urban dwellers.
Bernabe-Ortiz Antonio, Gilman Robert H., Smeeth Liam, Benziger Catherine Pastorius, Miranda J. Jaime, Gilman, Robert H, Catherine Pastorius Benziger, Liam Smeeth, Catherine Pastorius Benziger (172968), Robert H. Gilman (43897), Liam Smeeth (67156), Antonio Bernabe-Ortiz (90790), Antonio Bernabe-Ortiz, Smeeth, Liam, Miranda, J Jaime, Bernabe-Ortiz, Antonio, Robert H Gilman, J Jaime Miranda, Benziger, Catherine Pastorius, J. Jaime Miranda (5649565)   +19 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Should socioeconomic factors be considered as traditional risk factors for cardiovascular disease, as confounders, or as risk modifiers?

, 2008
A large number of studies show that cardiovascular disease and its traditional risk factors are associated with socioeconomic conditions. However, their etiological role in the development of cardiovascular outcomes is not always well understood ...
Marmot, M., De Vogli, R.
core  

Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies [PDF]

, 2011
BACKGROUND: Guidelines differ about the value of assessment of adiposity measures for cardiovascular disease risk prediction when information is available for other risk factors. We studied the separate and combined associations of body-mass index (BMI),
Nordestgaard, Borge G., Stehouwer, Coen; id_orcid, Kaptoge, S., Danesh, J, Wood, Angela M., Thompson, Alex, Sattar, N, Thompson, A, Wormser, D, Emerging Risk Factors Collaboration, Risérus, Ulf,, Salomma, V, Sarwar, N, Danesh, J., Wood, Angela M, Pennells, L, Ärnlöv, Johan,, Woodward, M., Salomaa, Veikko, Sundström, Johan,, Thompson, S.G., Kaptoge, S, Tybjærg-Hansen, Anne, Wormser, D., Ridker, P, Thompson, Simon G, null The Emerging Risk Factors Collaboration, Woodward, Mark, Kizer, Jorge R, Frikke-Schmidt, Ruth, Nordestgaard, BG, Kaptoge, Stephen, Salomaa, V, Lawlor, DA, Eriksson, Henry,, Sarwar, Nadeem, Wood, AM, Kizer, Jorge R., Pennells, Lisa, Stevens, June, Pennells, L., Whitlock, G, Salomaa, V., Nordestgaard, B.G., Collins, Rory, Ridker, Paul, Thompson, A., Lawlor, D.A., Woodward, M, Collins, R, Kizer, J.R., Sattar, N., Lawlor, Debbie A, Sarwar, N., Ingelsson, Erik,, Davey Smith, George, Danesh, John, Stehouwer, Coen, Ridker, P., The Emerging Risk Factors Collaboration,, Di Angelantonio, Emanuele, Wood, A.M., Whitlock, G., Di Angelantonio, E., Sattar, Naveed, Lawlor, Debbie A., Collins, R., Di Angelantonio, E, Kizer, JR, Whitlock, Gary, Thompson, SG, Nordestgaard, Børge G, Stevens, J, Wormser, David, Stevens, J., Thompson, Simon G.   +75 more
core   +1 more source

Australian adults' behaviours, knowledge and perceptions of risk factors for heart disease: A cross-sectional study

Preventive Medicine Reports, 2017
This research aimed to determine Australian adults' perceptions of risk factors for heart disease, self-reported behaviours relating to modifiable risk factors, and knowledge of leading causes of death.
Erin Hoare, Bill Stavreski, Bronwyn A. Kingwell, Garry L. Jennings   +3 more
doaj   +1 more source

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source