Results 111 to 120 of about 1,419,649 (316)

The impact of eplerenone at different levels of risk in patients with systolic heart failure and mild symptoms: insight from a novel risk score for prognosis derived from the EMPHASIS-HF trial.

, 2013
AIMS: Our objective was to create a simple prognostic risk score for patients with systolic heart failure and mild symptoms. We then assessed the efficacy of eplerenone across different categories of risk.
Swedberg, Karl, Van Veldhuisen, Dirk, Krum, H., Pocock, Stuart, Pocock, S. J., Zannad, Faiez, Vincent, J., McMurray, John JV, Zannad, F., Pitt, B., Collier, Timothy J., McMurray, J.J.V., Shi, H., Vincent, John, van Veldhuisen, Dirk J., Collier, Timothy J, Krum, Henry, van Veldhuisen, D.J., Swedberg, Karl,, Pocock, Stuart J, van Veldhuisen, D. J., van Veldhuisen, Dirk J, McMurray, J. J., McMurray, John J. V., Shi, Harry, McMurray, John, Collier, Timothy, Pocock, Stuart J., Collier, T. J., Pitt, Bertram, Swedberg, K.   +30 more
core   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Heart Diseases Associated Genes

, 2020
Background: Heart diseases are complex pathophysiologic conditions involving biomarkers. Understanding the mechanisms by which a gene selectively triggers intracellular molecular responses provide insight into the complex processes implicated in heart ...
Gheflat, Shivasadat, Bandehpour, Mojgan, Chegeni, Rouzbeh, Zahedipour, Fatemeh   +3 more
core   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Validation of a health literacy screening tool (REALM) in a UK population with coronary heart disease.

, 2008
BACKGROUND: Health literacy (HL) has been recognized as an important public health issue in other developed countries such as the US. There is currently no HL screening tool valid for use in the UK.
Gomez, GB, Chesnokov, Melanie, Rowlands, Gill, Reid, Fiona, Gomez, Gabriela B, Chesnokov, M, Shaw, A, Reid, F, Rowlands, G, Ussher, M, Shaw, Adrienne, Ibrahim, SY, Ussher, Michael, Ibrahim, Saima Y   +13 more
core   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Effectiveness of remote pulmonary artery pressure estimating in heart failure: systematic review and meta-analysis

Scientific Reports
Heart failure (HF) poses a significant challenge, often leading to frequent hospitalizations and compromised quality of life. Continuous pulmonary artery pressure (PAP) monitoring offers a surrogate for congestion status in ambulatory HF care.
Szymon Urban, Oskar Szymański, Magdalena Grzesiak, Wojciech Tokarczyk, Mikołaj Błaziak, Maksym Jura, Michał Fułek, Katarzyna Fułek, Gracjan Iwanek, Piotr Gajewski, Piotr Ponikowski, Jan Biegus, Robert Zymliński   +12 more
doaj   +1 more source

Assessment of coronary heart diseases in diabetics in al-Madinah al-Munawarah

, 2012
Omar al-Nozha1, Moaz Mojadadi2, Mohamed Mosaad1,3, Mohamed F El-Bab2,41Department of Medicine, 2Department of Physiology, College of Medicine, Taibah University, al-Madinah al-Munawarah, Kingdom of Saudi Arabia; 3Department of Medicine, 4Department of ...
al-Nozha O, El-Bab MF, Mojadadi M, Mosaad M   +3 more
core  

Dementia Incidence in Individuals With Parkinson's Disease in the Framingham Heart Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Limited information exists on incident dementia in individuals with Parkinson's disease (PD) in US community‐based samples. We examined cognitive statuses and PD diagnoses of 183 individuals in the Framingham Heart Study (FHS) to establish incident dementia, mortality rates, associations with sex, age at PD onset, and education level.
Joshi Dookhy, Michael Cummings, Eden Price, Yulin Liu, Santiago Gutierrez‐Gomez, Sarah O'Shea, Samuel Frank, Rhoda Au, Ashita S. Gurnani, Ting Fang Alvin Ang, Jesse Mez, Ludy C. Shih   +11 more
wiley   +1 more source