Results 31 to 40 of about 1,183,826 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling

, 2014
Grazia Daniela Femminella,1 Vincenzo Barrese,2,3 Nicola Ferrara,1,4 Giuseppe Rengo4 1Department of Translational Medical Sciences, Federico II University, Naples, Italy; 2Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II
Ferrara, N, Barrese V, Ferrara N, FERRARA, NICOLA, Rengo, G, Barrese, Vincenzo, FEMMINELLA, GRAZIA DANIELA, Femminella GD, Barrese, V, Rengo G, Femminella, GD, RENGO, GIUSEPPE   +11 more
core   +1 more source

Natriuretic Peptides in Chronic Heart Failure [PDF]

, 2019
Normal brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) levels are helpful in excluding chronic heart failure in the ambulatory setting, although they have been studied less well and possibly less accurately than in acute care.
Sandra Sanders-van Wijk, Brunner-La Rocca, Hanspeter, Hans-Peter Brunner-La Rocca, Brunner-La Rocca, Hanspeter; id_orcid, Sanders - van Wijk, Sandra   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The EuroHeart Failure survey programme—a survey on the quality of care among patients with heart failure in Europe Part 1: patient characteristics and diagnosis

, 2003
The European Society of Cardiology (ESC) has published guidelines for the investigation of patients with suspected heart failure and, if the diagnosis is proven, their subsequent management.
van Gilst, WH, Eastaugh, Joanne, Cohen-Solal, A., Gilst, W. H. van, Gavazzi, A, Freemantle, N, Cleland, JG, Gavazzi, A., Hobbs, Frederick, Moiseyev, VS, Dietz, R, van Gilst, W.H., Cleland, J.G., Hobbs, R, Korewicki, J., Follath, F., Hobbs, R., Mason, J., Eastaugh, J, Cohen-Solal, A, Préda, István, Cleland, JGF, Freemantle, Nick, Madeira, HC, Widimsky, J, Swedberg K Follath, F, Dietz, R., Cleland, J. G. F., Widimsky, J., Swedberg, K, Eastaugh, J., Preda, [No Value], Madeira, H. C., Moiseyev, V. S., Aguilar, JC, Aguilar, J.C., Komajda, M., Freemantle, N., Komajda, M, Preda, I., Korewicki, J, Aguilar, J. C., Mason, J, Madeira, H.C., Preda, I, Moiseyev, V.S., Swedberg, K., Follath, F   +47 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The brain in heart failure [PDF]

, 2004
After atrial fibrillation, heart failure is the second most frequent cardiac association of stroke. Deteriorating left ventricular systolic function appears to increase the risk of cardioembolic stroke in heart failure.
Pullicino, Patrick
core  

Plasma urocortin 1 in human heart failure.

, 2009
The urocortins are emerging as potentially important contributors to neurohumoral regulation of the circulation with recent reports attributing a powerful array of hemodynamic, renal, and neurohumoral effects to the urocortins in cardiac failure.
Gamble, Gregory, Richards, AM, Yandle, TG, Wright, SP, Frampton, CM, Doughty, Robert   +5 more
core   +1 more source