Results 41 to 50 of about 1,183,826 (262)

Modifiable lifestyle factors and heart failure: A Mendelian randomization study

, 2020
Background: Lifestyle factors may be important targets in the prevention of heart failure. The current knowledge on the relationship between lifestyle factors and heart failure originates mostly from observational studies. The objective of this study was
Handoko, M. Louis, Beulens, Joline W. J.,, Oort, Sabine van,, Handoko, M. Louis,, Beulens, Joline W.J., van Ballegooijen, Adriana J., Larsson, Susanna C., Larsson, Susanna C.,, van Oort, Sabine, Ballegooijen, Adriana J. van,   +9 more
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Mechanical unloading reverses transverse tubule remodelling and normalizes local Ca2+-induced Ca2+ release in a rodent model of heart failure [PDF]

, 2012
Aims Ca2+-induced Ca2+ release (CICR) is critical for contraction in cardiomyocytes. The transverse (t)-tubule system guarantees the proximity of the triggers for Ca2+ release [L-type Ca2+ channel, dihydropyridine receptors (DHPRs)] and the sarcoplasmic ...
Terracciano, CM, Navaratnarajah, M, Dias, P, Moshkov, AV, Rao, C, Siedlecka, U, Gorelik, J, Ibrahim, M, Yacoub, MH   +8 more
core   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Heart Failure

JACC: Heart Failure, 2013
Despite major improvements in the treatment of virtually all cardiac disorders, heart failure (HF) is an exception, in that its prevalence is rising, and only small prolongations in survival are occurring. An increasing fraction, especially older women with diabetes, obesity, and atrial fibrillation exhibit HF with preserved systolic function.
openaire   +2 more sources

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Ivabradine in Heart Failure

, 2017
Background: The sinus node inhibitor ivabradine was approved for patients with heart failure (HF) after the ivabradine and outcomes in chronic HF (SHIFT [Systolic Heart Failure Treatment With the IF Inhibitor Ivabradine Trial ...
Das, D., Ulf Dahlström, Justin A. Ezekowitz, Howlett, Jonathan,, Dahlstrom, U, Das, D, Lund, LH, Savarese, G,, Debraj Das, Fu, M, Lund, Lars H.,, Savarese, G., Gianluigi Savarese, Howlett, J, Michael Fu, Ezekowitz, Justin A.,, Ezekowitz, J. A., Lars H. Lund, Fu, Michael,, Jonathan Howlett, Das, Debraj,, Lund, L. H., Howlett, J., Dahlstrom, U., Dahlström, Ulf,, Savarese, Gianluigi,, Ezekowitz, JA   +26 more
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Heart failure – or a failure of imagination? [PDF]

Postgraduate Medical Journal, 2017
Over ten years ago, Richard Lehman wrote an editorial in the BMJ proposing that we should abandon the term heart failure.1 Instead, he suggested, ‘it might be kinder, and more accurate, to start calling it cardiac impairment.’ As Lehman argued, the term heart failure covers a confusingly wide spectrum of illness ranging from asymptomatic systolic ...
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times? [PDF]

, 2009
Chronic heart failure increases the risk of atrial fibrillation (AF), with the prevalence of AF paralleling the severity of heart failure.1 Factors that underlie this increased susceptibility to AF may include electrical, structural, and neurohumoral ...
Rankin, A.C., Workman, A.J.
core   +1 more source